简介：评估由于长期的心脏的失败为浮肿与中国植物粘住的acupoint的治疗学的效果。

简介：AIM:Tocomparetherapeuticeffectsofintravitrealtriamcinoloneacetonide(IVTA)versusintravitrealbevacizumab(IVB)injectionsforbilateraldiffusediabeticmacularedema(DDME).METHODS:Fortyeyesof20patientswithbilateralDDMEparticipatedinthisstudy.Foreachpatient,4mg/0.1mLIVTAwasinjectedtooneeyeand2.5mg/0.1mLIVBwasinjectedtotheothereye.Theeffectsofinjectionfordiabeticmacularedema(DME)wereevaluatedusingbest-correctedvisualacuity(BCVA),centralmacularthickness(CMT)byopticalcoherencetomography(OCT)andintraocularpressure(IOP)byapplanationtonometer.Patientsunderwenteyeexaminations,includingBCVA,CMT,andIOPatpre-injection,1,4,8,12and24wkafterinjection.Duringthefollow-up,secondinjectionswereperformedtoeyeswhichhaveCMTgreaterthan400μmat12wkforsalvagetherapy.RESULTS:BCVA(logarithmoftheminimumangleofresolution)atpre-injection,1,4,8,12and24wkafterinjectionwas0.71±0.19,0.62±0.23,0.63±0.12,0.63±0.13,0.63±0.14and0.61±0.24intheIVTAgroupand0.68±0.25,0.61±0.22,0.60±0.24,0.62±0.25,0.65±0.26and0.59±0.25intheIVBgroup,respectively.CMT(μm)atpre-injection,1,4,8,12and24wkafterinjectionwas544±125,383±96,335±87,323±87,333±92,335±61intheIVTAgroupand514±100,431±86,428±107,442±106,478±112,430±88intheIVBgrouprespectively.ReductionratiosofmeanCMTwere29%at1wk,38%at4wk,40%at8wk,38%at12wk,and38%at24wkintheIVTAgroup.SecondIVTAinjectionswereperformedtothe6eyes(30%)at12wk.ReductionratiosofmeanCMTwere16%at1wk,17%at4wk,14%at8wk,7%at12wk,and16%at24wkintheIVBgroup.SecondIVBinjectionswereperformedtothe15eyes(75%)at12wk.CONCLUSION:Thisstudyshowedearlierandmorefrequentmacularedemarecurrencesintheeyestreatedwithbevacizumabcomparedwiththeonestreatedwithtriamcinoloneacetonide.Triamcinoloneacetonidewasfoundtoprovidemoreefficientandlo

简介：Diabeticmacularedema(DME)isaretinalthickeninginvolvingthecenterofthemacula.Itisoneoftheseriouseyediseaseswhichaffectsthecentralvisionandcanleadtopartialorevencompletevisualloss.Theonlycureistimelydiagnosis,prevention,andtreatmentofthedisease.ThispaperpresentsanautomatedsystemforthediagnosisandclassificationofDMEusingcolorfundusimage.Intheproposedtechnique,firsttheopticdiscisremovedbyapplyingsomepreprocessingsteps.Thepreprocessedimageisthenpassedthroughaclassifierforsegmentationoftheimagetodetectexudates.Theclassifierusesdynamicthresholdingtechniquebyusingsomeinputparametersoftheimage.Thestageclassificationisdoneonthebasisofanearlytreatmentdiabeticretinopathystudy(ETDRS)givencriteriatoassesstheseverityofdisease.Theproposedtechniquegivesasensitivity,specificity,andaccuracyof98.27%,96.58%,and96.54%,respectivelyonpublicallyavailabledatabase.

简介：加中国药用的忿恨评估针灸的治疗学的功效并且在在击以后的半身麻痹对待影响手足的浮肿洗。

简介：Objective:Tostudythecorrelationbetweenbrainedema,elevatedintracranialpressure(ICP)andcellapoptosisintraumaticbraininjury(TBI).Methods:Inthisstudy,totally42rabbitsin7groupswerestudied.Sixoftheanimalswereidentifiedasacontrolgroup,andtheremaining36animalswereequallydividedinto6TBIgroups.TBImodelswereproducedbythemodifiedmethodofFeeney.Aftertheimpact,ICPofeachsubjectwasrecordedcontinuouslybyanICPmonitoruntiltheanimalwassacrificedatscheduledtime.Theapoptoticbraincellsweredetectedbyanterminaldeoxynucleotide-transferase-mediateddUTP-digoxigeninnickendlabeling(TUNEL)assay.Cerebralwatercontent(CWC)wasmeasuredwithadryingmethodandcalculatedaccordingtotheElliottformula.Then,ananalysiswasconductedtodeterminethecorrelationbetweenthecountofapoptoticcellsandtheclinicalpathologicalchangesofthebrain.Results:Apoptoticcellcountbegantoincrease2haftertheimpact,andreacheditsmaximumabout3daysaftertheimpact.ThepeakvalueofCWCandICPappeared1dayand3daysaftertheimpact,respectively.ApoptoticcellcounthadapositivecorrelationwithCWCandICP.Conclusions:InTBI,occurrenceofbrainedemaandICPincreasemightleadtoapoptosisofbraincells.Anytherapywhichcanrelievebrainedemaand/ordecreaseICPwouldbeabletoreduceneuronapoptosis,therebytoattenuatethesecondarybraindamage.

简介：AIMTo用光连贯断层摄影术(10月)并且到在奔流外科以后在糖尿病的眼睛估计斑点的量的变化估计开发的发生或有斑点的浮肿变得更坏(我)在糖尿病的眼睛与或没有先存在ME.METHODSIn这未来的、观察研究，经历了奔流外科的60个糖尿病的病人的92只眼睛在外科前被评估并且1，在用10月有斑点的厚度的外科以后的3mo在九有斑点的子字段与10月被测量定义b另外，开发的发生或我变得更坏在糖尿病的眼睛被分析与或没有先存在，ME.RESULTSThe中央子字段平均数厚度增加了21.0µ；m和25.5µ；在1点的m，3mo后续，分别地(P<；0.01)。内部戒指和外部戒指的平均厚度增加了14.2µ；m和9.5µ；在1mo的m，18.2µ；m和12.9µ；在3mo的m。中央包含我在3mo在12只眼睛发展了，包括4与先存在与先存在看中央包含和8只眼睛非中央包含了我。先存在的糖尿病的有斑点的浮肿(DME)显著地与中央包含被联系我开发(P<；0.001).CONCLUSIONA尽管增加是温和的，统计上重要的增加能在中央子字段以及perifoveal和parafoveal部门被检测。并且有在奔流外科以前的外科手术前的DME的眼睛在为开发中央包含的更高的风险我。

简介：Objective:Toexploretheeffectofdexamethasonebylocaltreatmentofcerebraledemaandbraindamageafterbraininjury.Methods:Twenty-tworabbitswereclassifiedinto2groups,GroupA(thecontrolgroup,n=11)andGroupB(thetreatedgroup,n=11).Anrabbitbraincontusionmodelwasmadebybonewindowplastybyextraduralhitting.Groupbwastreatedbylocalinfiltratingandsprayingofdexamethasoneatequidistancetolesions.GroupAwasgivennormalsalineinthesamewayasGroupB.Thechangesofmoistureinbraintissuesandserummyelinbasicprotein(MBP)wereobserved.Results:ThepercentageofwatercontentindamagedhemisphereinGroupAandGroupbwas81.7%±0.56%and79.45%±0.52%respectively.Therewasasignificantdifferencebetweenthe2groups(P<0.05).ThenormallevelofMBPwas1.66μg/L±0.71μg/L,whilethevalueofMBPinGroupAandGroupbwere5.98μg/L±2.08μg/Land3.15μg/L±1.09μg/Lseparately.ThelevelofMBPinGroupAandGroupBwerehigherthannormallevelandtherewasalsoasignificantdifferencebetweenGroupAandGroupB(P<0.05).Conclusions:TheresultsofourstudyshowedthatthebrainmoistureandMBPinserumwereincreasedafterbraininjurywhilereducedaftertreatmentwithdexamethasone.ItisdemonstratedthatlocaltreatmentofbraininjurywithdexamethasonehasanobvioustherapeuticeffectoncerebraledemaandserumMBP.

简介：Objective:ToobservetheeffectsofgangliosideGM1onreductionofbrainedemaandameliorationofcerebralmetabolismaftertraumaticbraininjury(TBI).Methods:AnacuteexperimentalclosedTBImodelinratswasinducedbyafluid-percussionbraininjurymodel.AtfiveandsixtyminutesafterTBI,theanimalswereintraperitoneallyinjectedbygangliosideGM1(30mg/kg)orthesamevolumeofsaline.Atthe6thhourafterTBI,effectsofgangliosideGM1orsalineonchangesofmeanarterialpressure(MAP),contentsofwater,lacticacid(LA)andlipipperoxidation(LPO)intheinjuredcerebraltissueswereobserved.Results:AfterTBI,MAPdecreasedandcontentsofwater,LAandLPOincreasedinbraininjurygroup;however,MAPwasbacktonormallevelsandcontentsofwater,LAandLPOdecreasedingangliosideGM1treatedgroup,comparedwiththoseinbraininjurygroup(P<0.05).Nosignificantdifferencebetweenthesalinetreatedgroupandthebraininjurygroup(P>0.05)wasobserved.Conclusions:GangliosideGM1doeshaveobviousneuroprotectiveeffectonearlyTBI.

简介：在反脉管的endothelial生长的一个年以后与有斑点的浮肿的分辨率和foveal消沉的恢复在眼睛报导foveal厚度减小为包含中心的糖尿病的有斑点的浮肿(DME)的因素(anti-VEGF)治疗.METHODSFoveal厚度与光连贯断层摄影术被估计决定中央子字段foveal厚度(CSFT)并且在有DME的42只眼睛的有斑点的体积(CSFT>275湥獴愠?潣灭牡摥琠?敨污桴?潣瑮潲?牧畯？

简介：AIMTo评估热门non-steroidal的预防管理的功效在糖尿病的病人的有斑点的浮肿追随者奔流外科上的反煽动性的药(NSAID)，并且在NSAID的类型之间比较(ketorolactromethamine0.4%并且nepafenac0.1%).METHODSGroup(控制)1作为一个安慰剂组接待了人工的眼泪代用品，(nepafenac)组2收到了热门nepafenac(ketorolac)0.1%，和组3收到了热门ketorolactromethamine0.4%。病人们在完成一个以后手术后地被检查为评估似胞的有斑点的浮肿(CME)的星期，一个月，二个月和三月间隔开发。主要学习结果在与光连贯地形学(10月)测量的中央有斑点的厚度(CMT)正在完成最好改正的视觉尖酸(BCVA)和变化76个病人的.RESULTSEighty眼睛在这研究被包括。BCVA在第三个月显示出统计上重要的差别手术后列在后面在上面在控制组和NSAID组(P=0.04)之间。在开始从的所有情况中的CMT有增加手术后第一个星期直到第三个月。CMT显示出控制组和NSAID组之间的统计上重要的差别从手术后第一个月直到第三个月(P=0.008，0.027，0.004)。在BCVA和外科手术前的10月CMT.CONCLUSIONProphylacticnepafenac和ketorolac组之间没有统计上重要的差别，手术后的NSAID可以在在跟随奔流外科的糖尿病的眼睛减少CME的频率和严厉有一个角色。

简介：AbstractPurpose:Hypertonic fluids such as mannitol and half-molar sodium lactate are given to treat intracranial hypertension in patients with severe traumatic brain injury (TBI). In this study, sodium lactate was compared to mannitol in patients with TBI to investigate the efficacy in reducing intracranial pressure (ICP).Methods:This study was a systematic review with literature research on articles published in any year in the databases of PubMed, ScienceDirect, Asian Journal of Neurosurgery, and Cochrane Central Register of Controlled Trials. The keywords were "half-molar sodium lactate", "mannitol", "cerebral edema or brain swelling", and "severe traumatic brain injury". The inclusion criteria were (1) studies published in English, (2) randomized control trials or retrospective/prospective studies on TBI patients, and (3) therapies including half-molar sodium lactate and mannitol and (4) sufficient data such as mean difference (MD) and risk ratio (RR). Data analysis was conducted using Review Manager 5.3.Results:From 1499 studies, a total of 8 studies were eligible. Mannitol group reduced ICP of 0.65 times (MD 0.65; p= 0.64) and improved cerebral perfusion pressure of 0.61 times (MD 0.61; p= 0.88), better than the half-molar group of sodium lactate. But the half-molar group of sodium lactate maintained the mean arterial pressure level of 0.86 times, better than the mannitol group (MD 0.86; p= 0.09).Conclusion:Half-molar sodium lactate is as effective as mannitol in reducing ICP in the early phase of brain injury, superior over mannitol in an extended period. It is able to prevent intracranial hypertension and give better brain tissue perfusion as well as more stable hemodynamics. Blood osmolarity is a concern as it increases serum sodium.

简介：

简介：AIMTo估计intravitrealtriamcinoloneacetonide(IVTA)的可能的好处注射作为为在有糖尿病的有斑点的浮肿(DME)的病人的有斑点的激光光致疑结(MLP)的预告的处理，.METHODSPublished使随机化有关MLP与或没有为DME的IVTA预告的处理的控制试用(RCT)从数据库CNKI被检索，Medline，EMbase，科学的网，和Cochrane图书馆。合格研究上的元分析用RevMan5.0软件被进行。二个调查者独立地估计了试用的质量并且提取了数据。主要结果措施在最好改正的视觉尖酸(BCVA)包括了变化，在中央有斑点的厚度(CMT)的差别并且不利事件报导特别地在后续时期以内提高了intraocular压力。结果用重量平均数差别(WMD)或机会风险被分享(或)与他们的相应95%信心间隔(CI)。改正效果或随机效果的模型被采用trials.RESULTSFinally取决于包括的异质，五独立RCT被识别并且使用了独自与MLP把MLP与IVTA预告的处理(131只眼睛)作比较(133只眼睛，控制组)。全面学习质量根据修改Jadad规模是相对更高的。元分析证明有IVTA预告的处理的MLP显著地在一，三和六个月减少了CMT(P=0.002，0.0003和0.04，分别地)，与MLP相比独自一个。IVTA预告的处理组证明在在一个月的BCVA的统计上重要的改进列在后面在上面作为与控制组(P=0.03)相比。在三月、六月列在后面在上面，向没有在组之间的统计意义，在IVTA预告的处理组改进视觉尖酸有一个有益的趋势(P=0.06并且0.20，分别地)。intraocular压力的举起的发生比在控制组在IVTA预告的处理组是显著地更高的(P<；0.0001)。出版偏爱的证据都不根据Begg的测试和Egger的测试是在场的。有在包括的studies.CONCLUSIONThis元分析的异质的底层显示有IVTA预告的处理的MLP以CMT有更好治疗学的效果减小并且更早(1mo)为有DME的病人的视觉改进

简介：AIM:Tocomparetheeffectsofintravitrealinjectionofbevacizumab(IVB)withintravitrealtriamcinoloneacetonide(IVTA)onthetreatmentofcystoidmacularedema(CME)secondarytoretinalveinocclusion(RVO).·METHODS:AliteraturesearchwasconductedusingPubMed,theCochraneCentralRegisterofControlledTrials,WebofScienceandtheChineseBiomedicalDatabase.Thecomparisonwasdividedintotwogroups,group1conductedcomparisoninbranchRVO(BRVO)orcentralRVO(CRVO),group2conductedcomparisoninischemic-RVOornonischemic-RVO.Pooledmeandifferences(MDs)forchangesinvisualacuity(VA),centralmacularthickness(CMT)andintraocularpressure(IOP)werecalculatedingroupsat4,12and24wkaftertreatmentrespectively.·RESULTS:EightstudiescomparingtheefficacyofIVBwithIVTAwereincludedintheMeta-analysis.Ingroup1,inBRVO,significantdifferencewasshownonthecomparisonofCMTat24wk(MD,-45.66;95%CI,-76.03to-15.28;P=0.003),IVBwaseffectiveonBRVOforatleast24wk;nosignificantdifferenceswerefoundinthecomparisonofVAateachtimepoints(P>0.05respectively).InCRVO,nosignificantdifferenceswerefoundinthecomparisonofVAorCMTbetweenIVBandIVTAateachtimepoints(P>0.05,respectively).Ingroup2,inischemic-RVO,significantdifferenceswereshowninthecomparisonofVA(MD,-0.28;95%CI,-0.42to-0.14;P<0.0001)andCMT(MD,-86.50;95%CI,-151.18to-22.43;P=0.008)at24wk;Innonischemic-RVO,nosignificantdifferencesweredemonstratedinthecomparisonofVAorCMTbetweenIVBandIVTAateachtimepoints(P>0.05,respectively).TheoccurrenceofhighIOPwasmuchlowerinIVBgroup.·CONCLUSION:ThisMeta-analysissuggestedthatIVBwaseffectiveindecreasingCMTinBRVOforatleast24wk,IVBismoreeffectiveonimprovingVAandreducingCMTinischemic-RVO.IVBismorepromisingonRVOthanIVTA.

简介：AbstractBackground:Our previous studies showed that topical application of mesenchymal stem cells (MSCs) improved functional recovery in rat traumatic brain injury (TBI) model, and hypoxic precondition further enhanced the therapeutic effects of MSCs. There was no previous study on the attenuation of cerebral edema by MSCs. We investigated whether topical application of normoxic and hypoxic MSCs could reduce cerebral edema in an experimental TBI model.Methods:Two million normoxic (N = 24) and hypoxic (N = 24) MSCs were applied topically to exposed the cerebral cortex in a controlled cortical impact (CCI) model. The MSCs were fixed in position with fibrin glue. No treatment was given to control animals (TBI only: n = 24). After surgery, four animals in each group were sacrificed daily (day 1 to day 6) for edema evaluation. Normal animals without TBI were used as reference (n = 4). The expressions of GFAP, AQP4, and MMP9 were also investigated by immunofluorescence staining and RT-PCR at day 3.Results:The edema peaked within 3 days after TBI. Compared with the control, hypoxic MSCs reduced brain water content significantly (p < 0.05). Both hypoxic and normoxic MSCs downregulated the expression of MMP9 and normalized AQP4 distribution to astrocyte end feet.Conclusion:Our preliminary study showed that topical application of hypoxic MSCs suppressed both vasogenic and cytotoxic edema formation.

简介：AIMTo评估联合反脉管的endothelial生长的功效和安全因素(VEGF)代理人，口头的glucocorticoid，和为有斑点的浮肿的激光光致疑结治疗(我)对.METHODSThis学习包括了的网膜的静脉吸藏(RVO)第二等16个病人与的16只眼睛联系RVO我。病人们开始与口头的泼尼松和一个intravitrealanti-VEGF代理人被对待。二个星期以后，病人们经历了标准激光光致疑结。改正最好的视觉尖酸(BCVA)，中央网膜的厚度(CRT)，和网膜的容器氧化在收到的12mo.RESULTSPatients上被检验1.43

简介：AIMTo与有斑点的浮肿在病人在中央子字段foveal厚度(CSFT)上为intravitrealbevacizumab注射的短期的效果调查预兆的因素(我)对.METHODSThis是的中央网膜的静脉吸藏(CRVO)第二等在由于CRVO为我与intravitrealbevacizumab注射对待的60只眼睛的回顾的研究。后续是三个月。光谱域的光连贯断层摄影术(SD10月)测量的早治疗糖尿病的Retinopathy学习(ETDRS)分数和CSFT被用来在改正最好的视觉尖酸(BCVA)观察变化。基线BCVA，CSFT，年龄，CRVO持续时间和似胞的有斑点的浮肿(CME)或subretinal液体(SRF)的存在作为bevacizumabinjections.RESULTSBCVA在3mo在基线从0.9logMAR改进了到0.6logMAR的intravitreal的效果的潜在的预兆的因素被分析，它从721µ在CSFT与重要减小被联系；m到392µ；在注射以后的m3mo。大约50%CME盒子和超过90%SRF盒子在3mo与一个完全的决定对治疗作出回应。年龄(P=0.036)和低基线CSFT(P=0.037)与好3月的预后被联系。病人>；60岁在3mo完成了更好的CME分辨率(P=0.031)和更低的CSFT(305µ；m对474µ；m，P=0.003).CONCLUSIONIntravitrealbevacizumab显著地在3mo以后与CRVO在病人改进了视觉尖酸和CSFT。老年和更低的基线CSFT是短期的CSFT结果的好预言者。对bevacizumab的网膜的厚度反应可能取决于CME而非SRF的决定。