简介:摘要目的探讨III期胃癌患者术后辅助紫杉醇、氟尿嘧啶类似物联合化疗后引起的中性粒细胞减少与生存的相关性。方法选取2008年1月至2012年1月间收治的III期胃癌患者211例,按照CTCAE的CIN程度分为G0组、G1-2组、G3-4组,均采用既定的化疗方案,连续治疗6个周期,每三个周期进行一次全面检查及评定,化疗结束后做好随访工作,直到2015年6月30日为止。结果到截止日,211例患者中,复发转移者203例(96.2%),无复发转移者8例(3.8%),死亡者191例(90.5%)。1年、2年、3年生存率分别为98.10%、73.93%、18.01%。中位DFS为13.1月,中位OS为31.9月。经过单因素分析,CIN程度、CIN时间以及病理分级对OS与DFS具有显著影响。COX多因素分析显示,OS方面,G1-2组大于G3-4组但都大于G0组。结论III期胃癌术后化疗中出现CIN预示更好的预后,未出现中性粒细胞减少则预示预后不良,说明化疗程度不够,早期发生CIN要比晚出现CIN预后好。
简介:摘要目的探讨三维适形剂量递增放疗至74GY联合化疗治疗不能手术的III期非小细胞肺癌的可行性以及患者是否从中受益。方法22例没有手术切除的III期患者入组,放疗第1天开始化疗,放疗期间予同期化疗2周期,放疗结束后继续巩固化疗2周期。化疗方案全部采用TP方案(泰素135-175mg/m2,卡铂AUC=5~6,3~4周为一周期)。三维适形放疗剂量递增至64-74GY(2GY/次/日,5次/周),以出现3级或以上的放射急性反应为限制剂量递增的标准。结果20例(91%)患者放疗剂量安全递增到74GY,有19例(87%)患者至少完成3周期化疗。总有效率70%(14/20),1年、2年的生存率分别为65%,50%。3/4级放射性损伤的发生率15%(3/20。其中2例放射性肺炎,1例放射性食管炎)。结论三维适形放疗剂量递增至74GY联合化疗治疗是可行的,患者可获得较好的近期疗效和可接受的毒副反应,期待进一步的临床试验。
简介:摘要目的研究III、IV期宫颈癌患者神经周浸润与5年生存率的关系。方法回顾分析II、IV期宫颈癌患者临床资料并进行5年随访,比较有神经周浸润和无神经周浸润患者5年生存率的差异。结果本组70例III、IV期宫颈癌患者中42例病理切片中检测到神经周浸润,神经周浸润发生率为60.0%,5年生存率为28.6%;无神经周浸润III、IV期宫颈癌患者5年生存率为46.4%,有神经周浸润III、IV期宫颈癌患者5年生存率为16.7%,无神经周浸润宫颈癌患者5年生存率显著高于有神经周浸润患者(P<0.05)。结论神经周浸润为初治宫颈癌患者预后不良指标,其发生率与KPS评分、分化程度、肿瘤最大径、淋巴结转移、远处转移和Figo分期,可反映病情严重程度。
简介:TheThirdWesternPacificRegionalAcousticsConference(WESTPACIII)washeldinNov.2-4,1988attheMagnollaHotelinShanghai.TheWESTPACIIIwasco-sponsoredbytheAcousticalSocietyofChina,theInstituteofAcousticsofAcademiaSinicaandtheAcousticalSocietyofShanghai.298scientistsandengineersfrom14countriesandareas,includingChina,Japan,Korea(South),India,HogngKong,NewZealand,Australia,Singapore,USA,GreatBritain,Denmark,Sweden,F.R.GermanyandIsrael,participatedintheWESTPACIII.TheopeningceremonywasheldinthemorningofNov.2.Prof.YingChongfu,Chairmanoftheorganizingcommitteemadetheopeningspeech.Intheplenaryses-sion,Prof.HiroyaFujisakifromUniv.ofTokyo,Japan,Prof.A.C.KibblewhitefromUniv.ofAuckland,NewZealandandProfWeiRongjuefromNanjingUniv.,
简介:ChinaandCanadahavesignedaprojectawardagreementfortheco-operationfortheQinshanPhaseⅢCandunuclearpowerproject,markingsignificantprogressincommercialnegotiationsbetweenbothcountriesontheconstructionoftwo700megawattclassCanduunits.Theagreement,signedbetweentheChinaNationalNuclearCorp(CNNC)andtheAtomicEnergyofCanadaLtd(AECL)inBeijingonJuly12,finalizedthepriceandcommercialtermsforQinshanPhaseⅢ
简介:摘要:课程思政是把立德树人作为一种教育根本的课堂教学理念。大学生思想政治教育工作是一件非常重要的人物,尤其是英语专业学生。由于英语专业学生长期接触外来文化,因此在教学过程中更应该将中国传统文化和正确的价值观融入进去。《英语写作III》作为英语专业基础课程,主要是教授各种英语文体的写作技巧,比如说明文、描写文等。本研究旨在探索将课程思政融入英语写作课程中,提升学生写作能力的同时,帮助学生了解传统文化以及树立正确的价值观。
简介:AbstractPurpose:To analyze the curative effect and technical points of a modified posteromedial approach in the treatment of Klammer III posterior Pilon fracture.Methods:A retrospective analysis of patients with Klammer III posterior Pilon fractures were conducted in our department from January 2018 to December 2019. Before the surgery, the patients were fully relieved of swelling and pain, and a comprehensive examination was carried out. The posteromedial approach exposed the posterior and medial fracture block of the distal tibia. According to the fracture of external malleolus, it is determined whether to combine a lateral incision and protect tendons and vascular nerves by a retractor, and then perform a fracture reduction and internal fixation. Postoperatively, the patients were treated with analgesia, detumescence, anticoagulation and rehabilitation exercise. The American orthopaedic foot and ankle society (AOFAS) score and visual analogue score were recorded at regular follow-up after surgery. A t-test was used for the comparison of the preoperative and final AOFAS score.Results:There were 7 male and 13 female (n = 20) included in the study, aged 22 to 88 years (average age 54.2 years). The injury mechanisms were falling from a height (n = 7), traffic accident (n = 6), walking injury (n = 2) and heavy injury (n = 5). The postoperative follow-up duration was 12—24 months (mean 16.95 months). The AOFAS score of the 20 patients before and after surgery were compared. The preoperative AOFAS score was 38.90 ± 3.91, and the final AOFAS score was 80.55 ± 4.20, (p < 0.001). The mean final visual analogue scores at rest, active and weight-bearing walking were 0.30, 0.85 and 1.70, respectively. One patient reported poor postoperative wound healing and required a return to hospital for debridement and anti-infection treatment.Conclusion:In the treatment of Klammer III posterior Pilon fractures, the modified posteromedial approach can fully expose the fracture block and the collapsed articular surface of the medial malleolus, achieve good reduction and internal fixation with limited injury of the tendon and vascular nerves, and have a better prognosis.
简介:Thesemightyfallsareoneofthegreatnaturalwondersoftheworldalthoughtheyarenot,infact,nearlythehighestintheworld-theKaieteurFalls,forinstance,inBritishGuianabeingfivetimesashigh.TheyarepartlyinCanadaandpartlyintheUnitedStates,astheboundarybetweenthetwocountriesfollowstheRiverNiagara.ThisflowsfromLakeErieintoLakeOntario,andinitscourse
简介:TheIGCCpowergenerationdemonstrationprojectinYantaiCity,ShandongProvinceistheState’scleancoalpowergenerationdemonstrationproject.Theconstructionscaleofthefirstphaseistobuildone300MWor400MWgeneratingunit,withreservedspaceforextension.Themainequipment,andmaind