摘要
Epilepsyisacommonneurologicaldisorder,anditselectrophysiologycharacteristicisabnormallyhighexcitabilityandsynchronizationoftheneuralactivity.Thispaperfocusesonthestudyofmedialtemporallobeepilepsywithhippocampalsclerosis.Thehippocampusplaysanimportantroleinshort-termmemory.However,littleisknownabouttheconnectivitybetweenhippocampalstructuresandadjacentbrainregions.Thefunctionalandstructuralconnectivitybetweenpatientsandcontrolswasinvestigatedbyusingthetechniquesoffunctionalmagneticresonanceimaginganddiffusiontensorimaginginthepaper.ThreepairsofROIsrelatedtoworkingmemoryfromBOLD-fMRIdatawerechosen.TheseROIswereregistratedfromMNIspacetoindividualspaceandthefiberbundlebetweentwoROIsweretracedintheDTIimages.TheresultsshowthatthenumberoffiberbundleofpatientsreduceamongtheseROIs,suchaslefthippocampusandrighthippocampus,lefthippocampusandleftthalamus,lefthippocampusandleftfrontallobeandsoon.AndthenumberoffiberbundleofpatientsincreaseamongtheseROIs,suchasleftthalamusandrightthalamus,righthippocampusandrightthalamus.AndtheFAvaluesofthefiberbundlesofpatientsinsomeregionsrelatedtolefthippocampusdecrease.Thecauseofabnormalfunctionalandstructuralconnectionsduetothedamageofhippocampusinmedialtemporallobeepilepsyisstudiedfromanewperspective.
出版日期
2013年02月12日（中国期刊网平台首次上网日期，不代表论文的发表时间）
