摘要
Cancercelldormancyisthemaincauseofcancerrecurrenceandfailureoftherapyasdormantcellsevadenotonlytheanticancerdrugsbutalsothehostimmunesystem.Thesedormantcellsveilthemselvesfromdetectionbyimagingand/orusingbiomarkers,whichimposesanadditionalproblemintargetingsuchcells.Asimilarformofhibernationprocessknownasencystationisstudiedindetailforpathogenicunicellulareukaryoticmicroorganisms.Byexaminationusingmicroarraygeneexpressionprofiles,immunocytochemistrytools,andsiRNAsduringtheprocessofencystation,understandingthecovertfeaturesofcancercelldormancyasproposedcouldbepossible.Thisknowledgecanbeextendedtodormantcancercellstouncoverthemechanismsthatunderliethisghost,yetdangerousstateofhumancancers.Weproposeastrategytoinducedormancyandexitthisstatebyapplicationofknowledgegainedfromtheencystationinductionandretrievalprocessesinpathogeniceukaryoticmicroorganisms.Giventhatearlydetectionandcharacterizationofdormantmalignanttumorcellsisimportantasageneralstrategytomonitorandpreventthedevelopmentofovertmetastaticdisease,thishomologymayenablethedesignoftherapiesthatcouldeitherawakethedormantcellfromdormancytomakeitavailablefortherapiesorprolongsuchaphasetomakecancerappearasachronicdisease
出版日期
2015年01月11日(中国期刊网平台首次上网日期,不代表论文的发表时间)