摘要
Wnt-1induciblesignalingpathway-1(WISP-1),alsoknownasCCN-4,belongstotheconnectivetissuegrowthfactor(CTGF)family.WISP-1isprimarilyexpressedinembryonicstemcellsandisinvolvedinadultorgandevelopment.WISP-1participatesinmanycellularprocesses,includingproliferation,differentiation,apoptosisandadhesion.Inaddition,WISP-1playsanimportantroleindiversepathophysiologicalprocesses,suchasembryonicdevelopment,inflammation,injuryrepairsandcancers.RecentstudiesshowedthatWISP-1washighlycorrelatedwithtumorprogressionandmalignanttransformation,whereasitplayedanoncogenicroleincolorectalcancer,cholangiocarcinoma,hepatocellularcarcinomaandbreastcancer.However,interestingly,WISP-1exertsatumorsuppressingroleinlungandprostatecancers.WISP-1promotescellproliferation,adhesion,motility,invasion,metastasisandepithelial-to-mesenchymaltransitionviaparticularsignalingpathways.Inthisreview,wediscussedthestructure,expressionprofile,functions,clinicalsignificanceandpotentialmechanismsofWISP-1incancerandnon-neoplasticdiseases.
出版日期
2016年06月16日（中国期刊网平台首次上网日期，不代表论文的发表时间）
