DELETION AND INACTIVATION OF RETINOBLASTOMA SUSCEPTIBILITY GENE IN PRIMARY RETINOBLASTOMA-中国期刊网

摘要 ThestatusandexpressionofRbgenewasdetectedandanalyzedin19surgicalretinoblastomaspecimensusingRbcDNA3.8kband0.9kbfragmentasprobeandantibodiesspecificforsyntheticRbpeptideorexpressiveproductofRbgeneexpressionplasmld.DNAfromthosetumorshadthehemlzygousdeletionin3cases,thehomozygousinternaldeletionIn2casesandalteratedrestrictionfragmentinvolvingInonecopyofRbgeneIn1case.ThequantityofRbproteindemonstratedeitherabsenceofreductioninallthe16casesexaminedIncomparisonwiththatinnormaladultretina.Itsuggestedthattherewerestructuralor/andfunctionaldefectsofRbgeneInretinoblastomacellsandprovidedevidencetosupportKnudson’stwohithypothesis.

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DELETION AND INACTIVATION OF RETINOBLASTOMA SUSCEPTIBILITY GENE IN PRIMARY RETINOBLASTOMA

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DELETION AND INACTIVATION OF RETINOBLASTOMA SUSCEPTIBILITY GENE IN PRIMARY RETINOBLASTOMA

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