Rapid response of brain metastasis to crizotinib in a patient with KLC1-ALK fusion and MET gene amplification positive non-small cell lung cancer：a case report-中国期刊网

摘要 Non-smallcelllungcancer(NSCLC)ranksastheleadingcauseofcancer-relateddeathintheworld.Brainmetastasis(BM)isacommoncomplicationofNSCLC,with25%–40%ofpatientsdevelopingBMduringthecourseofthedisease.Asignificantstrategyoflocaldiseasecontrolinthecentralnervoussystemisradiationtherapy.Withthedevelopmentofprecisionmedicine,theconceptoftreatinglungcancerBMhasgraduallychanged.Inthiscase,weperformedasurgicalproceduretoobtainenoughtumortissueforthedetectionofthetargetgeneandotherrelatedexperimentsafterthepatientwasinformed.Finally,wefoundthatthepatienthadbothhepatocytegrowthfactorreceptor(MET)geneamplificationandkinesinlightchain1-anaplasticlymphomakinasefusion(KLC1-ALK)throughnext-generationsequencingandshowedsensitivitytothetargetedtherapyofcrizotinib.Thepatientexhibitedgoodresponse.Ourcasewassuccessfulandunderwenttargetedtherapywiththeguidanceofprecisediagnosis.

1Ling Zhang;Yunxia Li;Shaohong Zhang;Chen Gao;Keke Nie;Youxin Ji. Primary resistance to crizotinib treatment in a non-small cell lung cancer patient with an EML4-ALK rearrangement：a case report.肿瘤,2018-02.
2Zhao Zhi-Mei,Wang Song-Ping,Sun Lei,Ji You-Xin. Crizotinib plus erlotinib overcomes osimertinib resistance in a seriously-ill non-small cell lung cancer patient with acquired MET amplification.医药卫生,2021-03.
3Puchun Er;Tian Zhang;Jing Wang;Qingsong Pang;Ping Wang. Brain metastasis in non-small cell lung cancer （NSCLC） patients with uncommon EGFR mutations： a report of seven cases and literature review.肿瘤,2017-04.
4Yu-Sook Jeong;Hye-Suk Han;Sung-Nam Lim;Mi-Jin Kim;Joung-Ho Han;Min-Ho Kang;Dong-Hee Ryu;Ok-Jun Lee;Ki-Hyeong Lee;Seung-Taik Kim. Gallbladder Metastasis of Non-small Cell Lung Cancer Presenting as Acute Cholecystitis.肿瘤,2012-03.
5Li Pei-Jie,Luo Jie,Liu Guang-E,Liu Da-Hai,Shen Sha-Sha,Li Xin-Juan,Ma Hu. Radiation therapy for patients with brain metastases from non-small cell lung cancer without driven gene mutation.医药卫生,2020-10.
6Marko NF Suh JH Chao ST Barnett GH Vogelbaum MA Toms S Well R J Angelov L. Gamma knife stereotactic radiosurgery for the management of incidentally-identified brain metastasis from non-small cell lung cancer.肿瘤,2011-01.
7Zhou Fei,Zhou Cai-Cun. Immunotherapy in non-small cell lung cancer: advancements and challenges.医药卫生,2021-05.
8Gui-Long Li;Yong Zhu;Wei Zheng;Chao-Hui Guo;Chun Chen. Analysis of factors influencing skip lymphatic metastasis in pN2 non-small cell lung cancer.肿瘤,2012-04.
9Arpita Desai;Smitha P.Menon;Grace K.Dy. Alterations in genes other than EGFR/ALK/ROS1 in non-small cell lung cancer：trials and treatment options.肿瘤,2016-01.
10Dmitriy Sergeevich Kobyakov;Ashot Merudzhanovich Avdalyan;Aleksandr Fedorovich Lazarev;Elena Leonidovna Lushnikova;Lev Moiseevich Nepomnyashchikh. Argyrophilic nucleolar organizer region in MIB-1 positive cells in non-small cell lung cancer： clinicopathological significance and survival.肿瘤,2014-04.

Rapid response of brain metastasis to crizotinib in a patient with KLC1-ALK fusion and MET gene amplification positive non-small cell lung cancer：a case report

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Rapid response of brain metastasis to crizotinib in a patient with KLC1-ALK fusion and MET gene amplification positive non-small cell lung cancer：a case report

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