Neurotrophic factors and corneal nerve regeneration-中国期刊网

摘要 Thecorneahasuniquefeaturesthatmakeitausefulmodelforregenerativemedicinestudies.Itisanavascular,transparent,denselyinnervatedtissueandanypathologicalchangescanbeeasilydetectedbyslitlampexamination.Cornealsensitivityisprovidedbytheophthalmicbranchofthetrigeminalnervethatelicitsprotectivereflexessuchasblinkingandtearingandexertstrophicsupportbyreleasingneuromediatorsandgrowthfactors.Cornealnervesareeasilyevaluatedforbothfunctionandmorphologyusingstandardinstrumentssuchascornealesthesiometerandinvivoconfocalmicroscope.Alllocalandsystemicconditionsthatareassociatedwithdamageofthetrigeminalnervecausethedevelopmentofneurotrophickeratitis,araredegenerativedisease.Neurotrophickeratitisischaracterizedbyimpairmentofcornealsensitivityassociatedwithdevelopmentofpersistentepithelialdefectsthatmayprogresstocornealulcer,meltingandperforation.Currentneurotrophickeratitistreatmentsaimatsupportingcornealhealingandpreventingprogressionofcornealdamage.Novelcompoundsabletostimulatecornealnerverecoveryareinadvanceddevelopmentstage.Amongthem,nervegrowthfactoreyedropsshowedtobesafeandeffectiveinstimulatingcornealhealingandimprovingcornealsensitivityinpatientswithneurotrophickeratitis.Neurotrophickeratitisrepresentsanusefulmodeltoevaluateinclinicalpracticenovelneuro-regenerativedrugs.

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Neurotrophic factors and corneal nerve regeneration

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Neurotrophic factors and corneal nerve regeneration

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