摘要
Recently,RNAprocessinghasemergedasanovelpathwaythatmaycontributetothemaintenanceofgenomestability[1].Alternativesplicingisakeymolecularmechanismforincreasingthefunctionaldiversityoftheeukaryoticproteomes,butitalsooftenalteredincancer.Mountingevidenceindicatesthatalternativesplicing,theprocessthatallowsproductionofmultiplemRNAvariantsfromeachgene,contributestotheheterogeneityofthedisease[2].Althoughthemechanismofalternativesplicingvariantincancerisunclear,thecancer-specificalternativesplicingvariantshavebeenobservedinavarietyofhumancancersandcancercelllinesandhavebeenconnectedtotumorgenesis.
出版日期
2015年01月11日(中国期刊网平台首次上网日期,不代表论文的发表时间)