摘要
Objective:ToexplorethepreparativemethodandstudythedegradationcharacteristicsofbonerepaircompositeofDL-polylacticacid(PDLLA)/hydroxyapatite(HA)/decalcifyingbonematrix(DBM)invitro.Methods:AnemulsionblendmethodwasdevelopedtopreparethecompositeofPDLLA/HA/DBMinweightratioofPDLLA:HA:DBM=1.5-2:1-1.5:1.Thedynamicchangesofweight,biomechanicalpropertyandpHvalueofPDLLA/HA/DBMandPDLLAinphosphatebufferedsaline(PBS,pH7.4)werestudiedrespectivelythroughdegradationtestsinvitro.Results:Withoutbeingheated,PDLLA,HAandDBMcouldbesynthesizedwiththeemulsionblendmethodasbonecompositeofPDLLA/HA/DBM,whichhadbothosteoconductiveandosteoinductiveeffects.Thediameteroftheaperturewas100-400μmandthegapratewas71.3%.Duringdegradation,thepHvalueofPDLLAsolutiondecreasedlightlywithin2weeks,butdecreasedobviouslyattheendof4weeksandthevaluewas4.0.WhilethepHvalueofPDLLA/HA/DBMkeptquitesteadyandwas6.4attheendof12weeks.TheweightofPDLLAchangedlittlewithin4weeks,thenchangedobviouslyandwas50%ofitsinitialweightattheendof12weeks.WhiletheweightofPDLLA/HA/DBMchangedlittlewithin5weeks,thenchangedobviouslyandwas60%oftheinitialweightattheendof12weeks.TheinitialbiomechanicalstrengthofPDLLAwas1.33MPa,decreasedlittlewithin3weeks,thenchangedobviouslyandkeptat0.11MPaattheendof12weeks.TheinitialbiomechanicalstrengthofPDLLA/HA/DBMwas1.7MPa,decreasedlittlewithin4weeks,thenchangedobviouslyandkeptat0.21MPaattheendof12weeks.Conclusions:Theemulsionblendmethodisanewmethodtopreparebonerepairmaterials.Asanewbonerepairmaterial,PDLLA/HA/DBMismoresuitableforregenerationandcellimplantation,andtheenvironmentduringitsdegradationisadvantageoustothegrowthofbonecells.
出版日期
2002年06月16日（中国期刊网平台首次上网日期，不代表论文的发表时间）
