摘要
Objective:Toanalyzelong-termoutcomeinsixtyleukemiapatientsreceivedallogeneichematopoieticstemcelltransplantation(allo-HSCT)followingbusulfanandcyclophosphamide(BU-CY2)between1994and2000.Methods:BU-CY2wasusedastheconditioningregimenandallo-HSCTwasperformedforallpatients.Allthepatientswerefollowed-upuntilAugust2001ordeath.Theleukemia-freesurvival,relapseandtransplant-relatedmortalitywerediscussed.Results:All60patientshadsustainedengraftment.AcuteGVHDoccurredin22outof60patients(36.7%),andtheincidenceofacuteGVHDwas48%inthepatientswithCML,30%inAMLand26.7%inALL.38patientsarestillaliveincontinuousremissionwithamedianfollow-upof30months(range12-84)and22patientshavedied.ThemaincausesofdeathwereacuteGVHDin3patients,CMV-IPin7patientsandrelapsein11patients,theremainingonediedofpulmonaryinfection.Among11patientswhodiedofrelapse,8patientswithALLrelapsedintheearlystageposttransplant(8/15,53.3%),relapsewasobservedintheremaining3patientswithAML,andhowever,norelapsewasobservedinCML.Theprobabilityofdisease-freesurvivalat3yearsforCML.AMLandALLpatientswas80%,70%and26.7%,respectively.Conclusion:ThisresultssuggeststhatBU-CY2isaneffectiveconditioningregimeninpatientswithAMLandCML,resultinginalowrelapserateandhighlong-termsurvivalrate,butnotaseffectiveinpatientswithALL,withahigherincidenceofrelapseandtherefore,notrecommendedforALLpatients.
出版日期
2003年03月13日（中国期刊网平台首次上网日期，不代表论文的发表时间）
