摘要
Objective:TostudytherelationshipbetweentheexpressionofBax,Bcl-2proteins,andapoptosisinradiationcompoundwoundhealingofrats.Methods:Apoptosis,BaxandBcl-2proteinswereestimatedbyinsituterminallabeling(TUNEL)andimmunohistochemicalmethods.Results:(1)Changesoftheapoptosisinwoundhealingshowedthreetypicalcharacteristics:earlyoccurrence,highfrequencyanddelayeddisappearanceafterradiationtoratswhencomparedwiththoseofsimplewoundgroup,whichmightbeanimportantreasonforradiation-induceddelayedwoundhealing.(2)TheexpressionofBaxproteinincreasedevidentlywiththeincrementofapoptosisandshowedagoodcorrespondingrelationshipwiththeapoptoticfrequencyintheprocessofwoundhealing.WhiletheexpressionofBcl-2proteindecreasedobviouslyastheapoptosisreachedamaximumandshowedincreasingtendencyuptonormallevelwhentheapoptosisdecreaseddistinctively.Conclusions:BaxandBcl-2proteinsplayanimportantroleintheapoptoticregulationofradiationcompoundwoundhealinginrats.
出版日期
2003年03月13日(中国期刊网平台首次上网日期,不代表论文的发表时间)