摘要
[摘要 ] 目的 探讨卡维地洛治疗心肌梗死后左心功能不全的疗效。 方法 选择 64例急性心肌梗死后合并左心功能不全患者随机分为卡维地洛组和对照组。两组患者均予以常规内科治疗，卡维地洛组加用卡维地洛 3.125 mg，每日 2次，逐渐加量，维持剂量 25 mg，每日 2次，连用 12个月。 结果 治疗 12个月后，两组患者彩色多普勒超声心动图 LVEDD、 LVESD、 LVEF数值均较治疗前明显改善（ P < 0.05或 P < 0.01），且卡维地洛组改善幅度明显优于对照组（ P < 0.05）。同时两组患者的 6 min步行试验均较治疗前明显升高（ P < 0.05或 P < 0.01），且卡维地洛组上升的幅度明显优于对照组（ P < 0.05）。治疗 12个月后，卡维地洛组临床治疗的总有效率及 12个月生存率高于对照组（ χ2=5.33、 4.27，均 P < 0.05），再次住院率明显低于对照组（ χ2=4.27， P < 0.05）。 结论 卡维地洛治疗心肌梗死后左心功能不全能有效防止左心室重构，改善左心功能，提高患者治疗有效率及生存率，降低再次住院率，改善患者生活质量及预后。
[关键词 ] 卡维地洛；心肌梗死；左心功能不全
[Abstract] Objective To investigate the effect of carvedilol on left ventricular dysfunction after myocardial infarction. Methods 64 patients with left ventricular dysfunction after acute myocardial infarction were randomly divided into carvedilol group and control group. The two groups were given routine medical treatment. The carvedilol group was given carvedilol 3.125 mg twice a day, gradually increasing the dose, maintaining the dose of 25 mg twice a day for 12 months. Results After 12 months of treatment, the values of LVEDD, LVESD and LVEF of color Doppler echocardiography in both groups were significantly improved compared with those before treatment (P < 0.05 or P < 0.01), and the improvement range of carvedilol group was significantly better than that of control group (P < 0.05). At the same time, the 6-minute walking test in both groups was significantly higher than that before treatment (P < 0.05 or P < 0.01), and the increase in carvedilol group was significantly better than that in control group (P < 0.05). After 12 months of treatment, the total effective rate and 12-month survival rate of carvedilol group were higher than those of control group (2 = 5.33, 4.27, P < 0.05), and the re-hospitalization rate was lower than that of control group (2 = 4.27, P < 0.05). Conclusion Carvedilol in the treatment of left ventricular dysfunction after myocardial infarction can effectively prevent left ventricular remodeling, improve left ventricular function, improve the treatment efficiency and survival rate of patients, reduce the re-hospitalization rate, improve the quality of life and prognosis of patients.
出版日期
2019年04月14日（中国期刊网平台首次上网日期，不代表论文的发表时间）
