摘要
摘要目的探讨老年晚期消化道肿瘤患者行卡培他滨单药连用３周方案治疗的临床疗效.方法将我院接收的６０例老年晚期消化道肿瘤患者随机分为观察组与对照组各３０例,均行卡培他滨治疗,对照组剂量为２５００mg/m２,２次服,连用２周,３周后重复;观察组剂量为２０００mg/m２,２次服,连用３周,４周后重复,对比两组疗效.结果两组患者经治疗后,对照组治疗总有效率为以６０．０％,观察组为６６．７％(P＞０．０５);对照组不良反应发生率以３６．７％明显高于观察组的１６．７％;观察组的生活质量明显优于对照组(P＜０．０５).结论老年晚期消化道肿瘤患者行卡培他滨单药连用３周方案治疗较之于连用２周治疗的疗效相当,但不良反应发生率低,且可改善患者生活质量,效果显著,具推广价值.AbstractObjectiveToinvestigateelderlypatientswithadvancedgastrointestinalcancerlinecapecitabinegemcitabinemonotherapyclinicalefficacyofonceeverythreeweeksregimen．Methods６０elderlypatientswithadvancedgastrointestinalcancerpatientsinourhospitalreceivedrandomlydividedintoobservationgroupandcontrolgroup,３０patientsweretreatedwithcapecitabine,thecontrolgroupatadoseof２５００mg/m２,２timesservice,onceeverytwoweeks,repeatedafter３weeks;observationgroupdoseof２０００mg/m２,２timesservice,onceeverythreeweeks,fourweeksaftertherepeatedcomparisonoftwogroups．ResultsThetwogroupsofpatientsaftertreatment,thecontrolgrouptotaleffectiveratewas６０．０％intheobservationgroupwas６６．７％(P＞０．０５);incidenceofadversereactionsto３６．７％inthecontrolgroupwassignificantlyhigherthanthe１６．７％intheobservationgroup;Observationqualityoflifewassignificantlybetterthanthecontrolgroup(P＜０．０５)．ConclusionsElderlypatientswithadvancedgastrointestinalcancerlinecapecitabinemonotherapygemcitabineregimenonceeverythreeweekstoonceeverytwoweekscomparedtheefficacyoftreatmentofequivalent,butthelowincidenceofadversereactions,andmayimprovethequalityoflifeofpatients,theeffectissignificant,withpromotionvalue．关键词卡培他滨;老年;晚期消化道肿瘤;不良反应中图分类号R７３５．２文献标识码B文章编号１００８－６３１５(２０１５)１２－０３７０－０２
出版日期
2015年12月22日（中国期刊网平台首次上网日期，不代表论文的发表时间）
