摘要
摘要目的分析腺苷蛋氨酸联合熊去氧胆酸治疗妊娠期内胆汁淤积症的临床效果.方法选择７０例妊娠期内胆汁淤积症患者作为研究对象,将随机分为对照组和观察组,每组３５例.其中对照组患者单纯使用腺苷蛋氨酸进行治疗,观察组患者采用熊去氧胆酸联合腺苷蛋氨酸联合熊去氧胆酸进行治疗.比较两组患者治疗前后血清总胆酸(TBA)、谷草转氨酶(AST)、谷丙转氨酶(ALT)、总胆红素(TB)变化情况,瘙痒评分得分情况以及妊娠结局.结果治疗后,所有患者的TBA、TB、AST、ALT以及瘙痒评分与治疗前相比均显著降低(P＜０．０５);治疗后观察组患者的TBA、TB、AST、ALT以及瘙痒评分显著低于对照组患者(P＜０．０５);观察组患者发生羊水污染、早产、新生儿窒息、新生儿体重异常等情况发生率显著低于对照组患者(P＜０．０５).结论腺苷蛋氨酸联合熊去氧胆酸治疗妊娠期内胆汁淤积症的临床治疗效果显著,能够明显改善患者的妊娠结局,制的临床推广使用.关键词妊娠期;胆汁淤积症;熊去氧胆酸;腺苷蛋氨酸AbstractObjectivetoanalysisofadenosinemethioninecombinedwithursodeoxycholicacidinthetreatmentofpregnancytheclinicaleffectofintrahepaticcholestasis．Methodsselect７０casesofpregnancyperiodcholestasispatientsastheresearchobject,wererandomlydividedintocontrolgroupandobservationgroup,３５casesineachgroup．Patientsofthecontrolgroup,patientsonlyademetioninetreatment,observationgrouppatientsweretreatedwithursodeoxycholicacidcombinedwithTransmetilcombinedbeardeoxycholicacid．Werecomparedbetweenthetwogroupsbeforeandaftertreatmentinpatientswithserumtotalbileacid(TBA),aspartateaminotransferase(AST),alanineaminotransferase(ALT),totalbileredhormone(TB),pruritusscoretoAndpregnancyoutcome．ReＧsultsaftertreatment,allpatientswithTBATB,AST,ALTandpruritusscorebeforetreatmentcomparedweresignificantlydecreased(P＜０．０５);aftertreatＧment,theobservationgroupofpatientswithTBATB,AST,ALTandpruritusscorewassignificantlylowerthanthatofcontrolgroup(P＜０．０５);patientsintheobservationgroupoccurredamnioticfluidpollution,prematurebirth,neonatalasphyxia,neonatalweightabnormaloccurrenceratewassignificantlylowerthanthatofthecontrolgroup(P＜０．０５)．ConclusionadenosinemethioninecombinedwithursodeoxycholicacidinthetreatmentofpregnancywithremarkableeffectkoefytwhoerdclinicaltreatmentofintrahepaticcholestasistosignificantlyimprovetheriskofThepregnancyoutcome,theclinicaluseofthesystem．pregnancy;intrahepaticcholestasis;ursodeoxycholicacid;s－ademetionine中图分类号R４５４文献标识码B文章编号１００８－６３１５(２０１５)１２－０１５２－０２
出版日期
2015年12月22日（中国期刊网平台首次上网日期，不代表论文的发表时间）
