首页 > 《中国保健营养》 > 2019年2期 > 盐酸坦索罗辛联合非那雄胺片对高龄高危良性前列腺增生患者血清TNF-α及PSA水平影响研究

盐酸坦索罗辛联合非那雄胺片对高龄高危良性前列腺增生患者血清TNF-α及PSA水平影响研究

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DOI rdx1kl0k4l/3286197

作者吴成璋

机构地区（青海省西宁市大通县人民医院泌尿外科青海西宁 810199 ）【摘要】目的：探究盐酸坦索罗辛联合非那雄胺片对高龄高危良性前列腺增生患者血清肿瘤坏死因子-α（Tumor necrosis factor-α，TNF-α）及前列腺特异抗原（Prostate specific antigen，PSA）水平影响。方法：64例高龄高危良性前列腺增生患者根据随机对照表分为对照组和试验组，其中试验组32例，对照组32例，2组均给予常规治疗和对症治疗，对照组给予非那雄胺片；试验组在对照组的基础上联用盐酸坦索罗辛胶囊。2组患者治疗1个周期，一个周期均为28d。治疗结束后对比分析2组临床疗效、最大尿流率、前列腺体积、残余尿量、国际前列腺症状(IPSS)评分、TNF-α、PSA水平以及不良反应。结果：治疗后2组最大尿流率水平升高（P＜0.05），与对照组相比，试验组最大尿流率水平较高（P＜0.05），2组前列腺体积、残余尿量、国际前列腺症状(IPSS)评分降低（P＜0.05），与对照组相比，试验组上述指标水平较低（P＜0.05）。治疗后2组TNF-α、PSA水平降低（P＜0.05），与对照组相比，试验组TNF-α、PSA水平较低（P＜0.05）。2组不良反应相比，差异无统计学意义。结论：盐酸坦索罗辛联合非那雄胺片对高龄高危良性前列腺增生患者的临床疗效显著，有效降低血清TNF-α及PSA水平。【

出处《中国保健营养》 2019年2期

关键词盐酸坦索罗辛非那雄胺片高龄高危良性前列腺增生肿瘤坏死因子-&alpha 前列腺特异抗原中图分类号R453 文献标识码A 文章编号1004-7484（2019）02-0114-02 Effect of Tamsulosin Hydrochloride combined with Finasteride Tablets on serum TNF- alpha and PSA levels in patients with senior and highly benign prostatic hyperplasia Wu Chengzhang. (Department of Urology Xining Dantong people's Hospital of Qinghai province Xining 810199 China) Abstractobjective to explore the Tamsulosin Hydrochloridecombined finasteride tablets in patients with senior and benign benign prostatic hyperplasia serum Tumor necrosis factor alpha (Tumor necrosis factor alpha TNF alpha) and Prostate specific antigen (Prostate specific antigen PSA) level. Methods 64 cases of senior and benign patients with benign prostatic hyperplasia according to random CRT is divided into control group and experimental group 32 cases of test group and control group in 32 cases two groups were given conventional treatment and symptomatic treatment the control group gi

分类 [医药卫生][公共卫生与预防医学]

出版日期 2019年02月12日（中国期刊网平台首次上网日期，不代表论文的发表时间）

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盐酸坦索罗辛非那雄胺片高龄高危良性前列腺增生肿瘤坏死因子-&alpha 前列腺特异抗原中图分类号R453 文献标识码A 文章编号1004-7484（2019）02-0114-02 Effect of Tamsulosin Hydrochloride combined with Finasteride Tablets on serum TNF- alpha and PSA levels in patients with senior and highly benign prostatic hyperplasia Wu Chengzhang. (Department of Urology Xining Dantong people's Hospital of Qinghai province Xining 810199 China) Abstractobjective to explore the Tamsulosin Hydrochloridecombined finasteride tablets in patients with senior and benign benign prostatic hyperplasia serum Tumor necrosis factor alpha (Tumor necrosis factor alpha TNF alpha) and Prostate specific antigen (Prostate specific antigen PSA) level. Methods 64 cases of senior and benign patients with benign prostatic hyperplasia according to random CRT is divided into control group and experimental group 32 cases of test group and control group in 32 cases two groups were given conventional treatment and symptomatic treatment the control group gi

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