摘要
Single-IonMicrobeam(SIM)isuniquelycapableofpreciselydeliveringapredefinednumberofchargedparticles(precisedosesofradiation)toindividualcellsorsub-cellulartargetsinsitu.Sincetheearly1990's,therehasbeenanever-increasinginterestindevelopingandapplyingtheSIMtechniquetoproblemsinradiobiologyforstudiesofcellandtissuedamagedbyionizingradiations.PotentialapplicationsforSIMinradiobiologycontinuestogrowandhavebeendiversified.Therearecurrentlymorethan14SIMfacilitiesworldwide,andtheyhavebeeninaconstantstateofevolution.ThispaperreviewsthecurrentstateofSIMresearchworldwideandtherelatedpivotaltechnologicaldevelopmentsinthefieldsofbothbiophysicsandradiobiology.RepresentativeapplicationsandtheperspectiveofSIMarealsointroducedanddiscussed.
出版日期
2005年02月12日（中国期刊网平台首次上网日期，不代表论文的发表时间）
