摘要
摘要目的探讨KLF４、Sp１、Notch１在胃癌中的表达关系,揭示其与胃癌病理学的相关性.方法本次研究中使用免疫组织化学法分析１５例正常组织样本３和５０例胃癌组织样本中KLF４、Sp１及Notch１蛋白水平,并分析三者４表达水平与胃癌临床病理间的相关性.结果５在胃癌组织中KLF４、Sp１及Notch１阳性表达率显著高于正常组(P＜０．０５);KLF４在高、中、低分化型胃癌组织中的阳性率分型间差异具有统计学意义(P＜０．０５),Sp１及Notch１在高、中、低分化型胃癌组织中的阳性率差异无统计学意义(P＞０．０５);淋巴转移组患者其KLF４、Sp１及Notch１阳性率均显著高于无转移组(P＜０．０５).不同临床样本分级患者间KLF４、Sp１及Notch１阳性率差异存在统计学意义(P＜０．０５).结论KLF４、Sp１、Notch１在胃癌的病发及发展的病理学过程中起着十分重要的作用,且可能成为下一代治疗胃癌的全新靶点,为胃癌的临床治疗提供新的途径.关键词KLF４;Sp１;Notch１;胃癌病理;相关性AbstractObjectiveToinvestigatetheexpressionof,Sp１andKLF４ingastriccancer,andtorevealthecorrelationbetweentheexpressionof,Notch１andgastriccancer．MethodsthelevelsofSp１,Notch１andKLF４proteinin５０casesofgastriccancertissueswereanalyzedbyimmunohistochemicalmethodin１５casesofgastriccancertissues,andthecorrelationbetweenthethreeandtheclinicalpathologyofgastriccancerwasanalyzed．ResultsthepositiveratesofNotch１,Sp１andKLF４weresignificantlyhigherthanthoseinnormalgroup(P＜０．０５),KLF４,Notch１andSp１inhigh,mediumandlowdifferentiatedgastriccancertissuesweresignificantlyhigherthanthoseinnormalgroup(P＞０．０５)．ThepositiveratesofP＜０．０５,Notch１andKLF４weresignificantlyhigherthanthosewithoutmeＧtastasis(Sp１)．ThereweresignificantdifferencesinNotch１,Sp１andKLF４amongdifferentclinicalsamples(P＜０．０５)．ConclusionKLF４,Sp１andNotch１playanimportantroleinthepathologicalprocessofgastriccancer,andmaybecomeanewtargetforthenextgenerationofgastriccancer,andprovideanewwayforthecliKniecyalwotrrdesatmentofgastriccancer．KLF４;Sp１;Notch１;gastriccancerpathology;correlation中图分类号R７３５．２文献标识码B文章编号１００８－６３１５(２０１５)１２－０７９０－０２６
出版日期
2015年12月22日（中国期刊网平台首次上网日期，不代表论文的发表时间）
