摘要
摘要目的探讨左氧氟沙星联合卷曲霉素治疗方案对耐药肺结核患者免疫功能及肝功能的影响.方法选择９０例多耐药肺结核患者为研究对象,采用随机数字表法分为观察组和对照组各４５例,对照组给予常规化疗＋护肝治疗,观察组在常规化疗＋护肝治疗的同时联合应用左氧氟沙星＋卷曲霉素治疗.比较两组免疫功能与肝功能.结果观察组免疫球蛋白IgG、IgA及IgM值均高于对照组(P＜０．０５);两组血清碱性磷酸酶(ALP)、门冬氨酸转氨酶(ALT)、丙氨酸转氨酶(AST)及总胆红素(STB)均明显低于治疗前(P＜０．０５),组间比较无统计学意义(P＞０．０５).结论左氧氟沙星联合卷曲霉素治疗方案有助于改善多耐药肺结核患者免疫功能,且不会对患者肝功能造成损害.关键词左氧氟沙星;卷曲霉素;多耐药肺结核;免疫功能;肝功能TheimpactofimmunefunctionandliverfunctionoflevofloxacincombinedcapreomycinforMultidrugresistantpulmonarytuberculosisAbstractobjectiveTostudyeffectofimmunefunctionandliverfunctionoflevofloxacincombinedcapreomycinforMultidrugresistantpulmonarytubercuＧlosis．Methods９０casespatientswithmulti－drugresistanttuberculosispatientsweredividedintoobservationgroupandcontrolgroup,controlgroupgivenconＧventionalchemotherapy＋protectliver,theobservationgroupcombinedlevofloxacin＋capreomycintherapy,immunefunctionandliverfunctionwerecomparedbetweentwogroups．ResultObservationgroupIgG,IgAandIgMvaluesweresignificantlyhigherthancontrolgroup(P＜０．０５);TwogroupsALP,ALT,AST,STBweresignificantlylowerthanbeforetreatment(P＜０．０５),therewerenostatisticalsignificancebetweentwogroups(P＞０．０５)．ConclusionLevoＧfloxaciKnecyowmobridnsedcapreomycinhelptoimproveimmunefunction,andliverfunctiondamage．Levofloxacin;Capreomycin;Multidrugresistantpulmonarytuberculosis;Immunefunction;Liverfunction中图分类号R５２１文献标识码B文章编号１００８－６３１５(２０１５)１０－０１６８－０１
出版日期
2015年09月19日（中国期刊网平台首次上网日期，不代表论文的发表时间）
