Recombinant Human Prolactin Protects against Irradiation-Induced Myelosuppression-中国期刊网

摘要 Prolactinisamultifunctionalhormonethatexertsmanyseparatefunctionsandactsasanimportantconnectionbetweentheendocrineandimmunesystems.Thereareincreasingresearchesimplicatingtheroleofprolactininhematopoiesis.Enhancederythropoiesisinpregnantwomenanddirecterythropoieticeffectsinvitroofplasmaeitherfrompregnantorlactatingmicehavebeenreported.Furthermore,regressionoferythroblasticleukemiahasbeenobservedinasignificantnumberofratsafterhypophysectomy.Inthisstudy,theeffectsofrecombinanthumanprolactin(rhPRL)onhematopoiesiswereassessedinirradiatedmice.MiceweretreatedwithrhPRLforfiveconsecutivedaysafterexposuretoalethaldoseorasub-doseirradiation.Prolongedsurvivalrateandincreasederythropoiesiswereobservedintheirradiation-inducedmyelosuppressivemice.ItwasconcludedthatrhPRLmightactonerythropoiesisandcouldbeapotentialcandidateforthetreatmentofirradiation-inducedmyelosuppresioninclinic.Cellular&MolecularImmunology.

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Recombinant Human Prolactin Protects against Irradiation-Induced Myelosuppression

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Recombinant Human Prolactin Protects against Irradiation-Induced Myelosuppression

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