摘要
[摘要 ] 目的 剖析第三代头孢菌素类抗菌药物药理作用及其临床合理用药。方法 回顾分析 2018年 9月— 2019年 7月期间我院头孢菌素类抗菌药物使用情况，随机抽取 500份医嘱作为研究对象，观察此类药物的使用频度、不良反应等。结果 ①第三代头孢菌素类抗菌药物的使用频度 28.23%，高于第二代的 9.76%，高于第一代的 8.56%，数据对比差异有统计学意义（ P<0.05）。②选取其中常用的 3种第三代头孢菌素类抗菌药物，头孢曲松、头孢地嗪钠、头孢噻肟钠，三种药物成人用药多选择静脉滴注、肌肉注射等方式用药，药理作用有所不同。③ 31例出现不良反应，不良反应涉及泌尿系统、血液系统、消化系统等方面不良反应。其中发生率最高的不良反应为消化系统不良反应，占全部不良反应的 77.42%。过敏反应明显高于其他不良反应类型发生率（ P<0.05）。 结论 该院使用的第三代头孢菌素类抗菌药物比较合理，因此严格掌握各种药物的药理，才能更好的确保临床上的合理用药。
[关键词 ] 第三代；头孢菌素类；抗菌药物；药理作用；合理用药
[Abstract] Objective To analyze the pharmacological action and clinical rational use of the third generation cephalosporins. Methods Retrospective analysis of the use of cephalosporins in our hospital from September 2018 to July 2019. 500 orders were randomly selected as the study object to observe the frequency of use and adverse reactions. Results ① the frequency of the third generation cephalosporins was 28.23%, higher than that of the second generation (9.76%), higher than that of the first generation (8.56%). ② three kinds of third generation cephalosporins, ceftriaxone, cefodizime and cefotaxime, which are commonly used in adults, were selected for intravenous drip and intramuscular injection, with different pharmacological effects. ③ 31 cases had adverse reactions, including urinary system, blood system and digestive system. The highest incidence of adverse reactions was digestive system adverse reactions, accounting for 77.42% of all adverse reactions. The incidence of anaphylaxis was significantly higher than that of other types of adverse reactions (P < 0.05) Conclusion the third generation cephalosporins used in the hospital are reasonable, so it is better to master the pharmacology of all kinds of drugs to ensure the rational use of drugs in clinical.
出版日期
2020年01月09日（中国期刊网平台首次上网日期，不代表论文的发表时间）
