摘要
[摘要 ] 目的 探究在治疗妊娠期糖尿病孕妇中应用盐酸二甲双胍 +门冬胰岛素治疗对孕妇血清胱抑素 C、同型半胱氨酸及母婴结局的影响。方法 随机抽取 2016年 6月— 2018年 6月该院收治的 84例妊娠期糖尿病孕妇，并根据入院顺序将其分为对照组与观察组两组（ n=42）。对照组采用门冬胰岛素治疗，观察组采用盐酸二甲双胍 +门冬胰岛素治疗。比较两组治疗前后临床各项情况。结果 治疗前，两组血糖指标水平与血清 CysC、 Hcy水平比较差异无统计学意义（ P>0.05）；治疗后，观察组血糖指标水平与血清 CysC、 Hcy水平优于对照组，差异有统计学意义（ P<0.05）；观察组婴巨大、早产、剖宫产等不良母婴结局发生率低于对照组，差异有统计学意义（ P<0.05）。结论 在治疗妊娠期糖尿病孕妇中应用盐酸二甲双胍 +门冬胰岛素治疗可有效控制孕妇血糖水平与血清 CysC、 Hcy水平，并改善其母婴结局，故具有更高临床应用价值。
[关键词 ] 盐酸二甲双胍；门冬胰岛素；妊娠期糖尿病孕妇；血清 CysC；母婴结局
[Abstract] Objective To explore the effect of metformin hydrochloride plus insulin aspart on serum cystatin C, homocysteine and maternal and infant outcome in the treatment of gestational diabetes. Methods 84 pregnant women with gestational diabetes were randomly selected from June 2016 to June 2018, and divided into control group and observation group according to the order of admission (n = 42). The control group was treated with aspartic insulin, and the observation group was treated with metformin hydrochloride + aspartic insulin. The clinical conditions of the two groups before and after treatment were compared. result Before treatment, there was no significant difference between the two groups in blood glucose index level and serum CysC, Hcy level (P>0.05); after treatment, the observation group was better than the control group in blood glucose index level and serum CysC, Hcy level, and the difference was statistically significant (P<0.05); the observation group was lower than the control group in the incidence of adverse maternal and infant outcomes, such as fetal macrosomia, premature delivery, cesarean section, and the difference was statistically significant (P<0.05) ) Conclusion metformin hydrochloride plus insulin aspart can effectively control the blood glucose level, serum CysC and Hcy levels in pregnant women with gestational diabetes mellitus, and improve the maternal and infant outcomes, so it has a higher clinical application value.
出版日期
2020年06月12日（中国期刊网平台首次上网日期，不代表论文的发表时间）
