摘要
摘要BACKGROUND AND OBJECTIVESTranscranial magnetic stimulation may represent an effective means for improving motor function in the elderly. The aim of this study was therefore to investigate the effects of paired associative stimulation (PAS; a plasticity-inducing transcranial magnetic stimulation paradigm) on acquisition of a novel visuomotor task in young and older adults.METHODSFourteen young (20.4±0.6 years) and 13 older (69.0±1.6 years) adults participated in 3 experimental sessions during which training was preceded (primed) by PAS. Within each session, the interstimulus interval used for PAS was set at either the N20 latency plus 5 ms (PASLTP), the N20 latency minus 10 ms (PASLTD), or a constant 100 ms (PASControl).RESULTSAfter training, the level of motor skill was not different between PAS conditions in young subjects (all p-values > 0.2), but was reduced by both PASLTP (P＝0.02) and PASLTD (P＝0.0001) in older subjects.CONCLUSIONPriming PAS was detrimental to skill acquisition in older adults, possibly suggesting a need for interventions that are optimized for use in elderly populations.
出版日期
2020年08月10日（中国期刊网平台首次上网日期，不代表论文的发表时间）
