摘要
AbstractStroke is a devastating disease that occurs when a blood vessel in the brain is either blocked or ruptured, consequently leading to deficits in neurological function. Stroke consistently ranked as one of the top causes of mortality, and with the mean age of incidence decreasing, there is renewed interest to seek novel therapeutic treatments. The Scavenger Receptor Class B type 1 (SR-B1) is a multifunctional protein found on the surface of a variety of cells. Research has found that that SR-B1 primarily functions in an anti-inflammatory and antiatherosclerotic capacity. In this review, we discuss the characteristics of SR-B1 and focus on its potential correlation with the modifiable risk factors of stroke. SR-B1 likely has an impact on stroke through its interaction with smoking, diabetes mellitus, diet, physical inactivity, obesity, hypercholesterolemia, atherosclerosis, coronary heart disease, hypertension, and sickle cell disease, all of which are critical risk factors in the pathogenesis of stroke.
机构地区
Burrell College of Osteopathic Medicine, Las Cruces, NM 88003, USA; Center for Neuroscience Research, School of Medicine, Loma Linda University, Loma Linda, CA 92324, USA,Center for Neuroscience Research, School of Medicine, Loma Linda University, Loma Linda, CA 92324, USA; Department of Neurosurger
出版日期
2020年08月13日（中国期刊网平台首次上网日期，不代表论文的发表时间）
