摘要
Shorttandemrepeats(STRs)areshorttandemlyrepeatedDNAsequencesthatinvolvearepetitiveunitof1–6bp.Becauseoftheirpolymorphismsandhighmuta-tionrates,STRsarewidelyusedinbiologicalresearch.Strand-slippagereplicationisthepredominantmutationmechanismofSTRs,andthestepwisemutationmodelisregardedasthemainmutationmodel.STRmutationratescanbeinfluencedbymanyfactors.Moreover,sometrinucleotiderepeatsareassociatedwithhumanneurodegenerativediseases.InordertodeepenourknowledgeofthesediseasesandbroadenSTRapplication,itisessentialtounderstandtheSTRmutationpro-cessindetail.Inthisreview,wefocusonthecurrentknowninformationaboutSTRmutation.
出版日期
2007年01月11日(中国期刊网平台首次上网日期,不代表论文的发表时间)