EFFECT OF ARSENIC TRIOXIDE OR ATRA ON PRIMARY APL CELL OR HL-60 CELLS AND THEIR VALUE ANALYSIS IN HYPERLEUKOCYTOSIS-中国期刊网

摘要 Objective:TodetecttheeffectofarsenictrioxideorATRAonAPLcellsorHL-60cellsandtoinvestigatethemechanismofthehyperleukocytosisanddetectthecrossresistancebetweenATRAandarsenictrioxide.Methods:Thenumberofpromyelocytesormorematuredgranulocyteswerecountedbyregularmethod,MTTtestwasusedtomeasuretheproliferationofHL-60cellsorAPLcells,flowcytometryanalysistomeasuretheapoptosis,NBTmethodtodetectthedifferentiationofHL-60cellsorAPLcells.Results:TheproliferationofprimaryAPLcellsorHL-60cellscouldbeinhibitedinvitrobyeitherarsenictrioxideorATRA,whichcouldinduceobviousapoptosisorobviousdifferentiationofprimaryAPLcellsorHL-60cells.InhibitionofproliferationorapoptosisofATRAresistantHL-60cellswereachievedbyexposuretoarsenictrioxideinvitro.Ontheotherhand,theresultsofinvivotreatmentshowedthatarsenictrioxidealsoinduceofhyperleukocytosis.Conclusion:TheresultsindicatedthatthehyperleukocytosisinducedbyATRAisnotcontributedtothemechanismofmoredifferentiationthanapoptosis,therewasnotcrossresistancebetweenATRAandarsenictrioxide.

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EFFECT OF ARSENIC TRIOXIDE OR ATRA ON PRIMARY APL CELL OR HL-60 CELLS AND THEIR VALUE ANALYSIS IN HYPERLEUKOCYTOSIS

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EFFECT OF ARSENIC TRIOXIDE OR ATRA ON PRIMARY APL CELL OR HL-60 CELLS AND THEIR VALUE ANALYSIS IN HYPERLEUKOCYTOSIS

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