The structural analysis of protein sequences based on the quasi-amino acids code

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摘要 Proteomicsisthestudyofproteinsandtheirinteractionsinacell.WiththesuccessfulcompletionoftheHumanGenomeProject,itcomesthepostgenomeerawhentheproteomicstechnologyisemerging.Thispaperstudiesproteinmoleculefromthealgebraicpointofview.Thealgebraicsystem(Σ,+,)isintroduced,whereΣisthesetof64codons.Accordingtothecharacteristicsof(Σ,+,),anovelquasi-aminoacidscodeclassificationmethodisintroducedandthecorrespondingalgebraicoperationtableoverthesetZUofthe16kindsofquasi-aminoacidsisestablished.Theinternalrelationisrevealedaboutquasi-aminoacids.Theresultsshowthatthereexistsomeveryclosecorrelationsbetweenthepropertiesofthequasi-aminoacidsandthecodon.Allthesecorrelationrelationshipsmayplayanimportantpartinestablishingthelogicrelationshipbetweencodonsandthequasi-aminoacidsduringthecourseoflifeorigination.AccordingtoMaFetal(2003J.AnhuiAgriculturalUniversity30439),thecorrespondingrelationandtheexcellentpropertiesaboutaminoacidscodeareverydifficulttoobserve.Thepresentpapershowsthat(ZU,⊕,)isafield.Furthermore,theoperationalresultsdisplaythatthecodontgahasdifferentpropertyfromotherstopcodons.Infact,inthemitochondrionfromhumanandoxgenomiccodon,tgaisjusttryptophane,isnotthestopcodonlikeinothergeneticcode,itisthecaseoftheChenWCetal(2002ActaBiophysicaSinica18(1)87).Thepresenttheoryavoidssomeinexplicableeventsofthe20kindsofaminoacidscode,inotherwordsitsolvestheproblemof'the64codonassignmentsofmRNAtoaminoacidsisprobablycompletelywrong'proposedbyYang(2006ProgressinModernBiomedicine63).
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出处 《中国物理B:英文版》 2009年1期
出版日期 2009年01月11日(中国期刊网平台首次上网日期,不代表论文的发表时间)
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