PERIPHERAL HEARING LOSS CAUSES HYPEREXCITABILITY OF THE INFERIOR COLLICULUS-中国期刊网

摘要 Growingevidencehasbeenfoundtosuggestthatearlydevelopmentofthecentralauditorysystemisdependentonacousticstimuli.Peripheraldamagecausedbynoiseexposureandototoxicdrugscaninducefunctionalandanatomicalchangesalongtheauditorypathways.Theinferiorcolliculus(IC)isauniquestructureintheauditorysystemlocatedbetweentheprimaryauditorynucleiofthebrainstemandthethala-mus.DamagetotheICinhibitorycircuitrymayaffectcentralauditoryprocessingandsoundperception.Here,wereviewsomeofthestrikingelectrophysiologicalchangesintheICthatoccurafternoiseexposureandototoxicdrugtreatment.AcommonoccurrencethatemergesintheICafterperipheraldamageishyper-excitabilityofsound-evokedresponse.ThehyperexcitabilityoftheICislikelyrelatedwithreducedinhibi-toryresponsethatrequiresnormalperipheralinputs.Earlyagehearinglosscanresultinalonglastingin-creasedsusceptibilitytoaudiogenicseizurewhichisrelatedtohyperactivityintheICevokedbyloudsounds.OurstudiessuggestthathearinglosscancauseincreasedICneuronresponsivenesswhichmayberelatedtotinnitus,hyperacusis,andaudiogenicseizure.

1. anatomy and physiology of peripheral auditory system and commen causes of hearing loss.耳鼻咽喉科,2009-01.
2LIU Ke;WANG Xiaoyu;LI Sijun;TANG Siquan;XU Yice;WANG Xuefeng;SUN Jianhe;YANG Weiyan;YANG Shiming. LOWER DOSE OF AMINOGLYCOSIDE OTOTOXIC EXPOSURE CAUSES PRESYNAPTIC ALTERATIONS ASSOICATED WITH HEARING LOSS.耳鼻咽喉科,2014-01.
3Brittany Mott;SUN Wei. FIRING PROPERTY OF INFERIOR COLLICULUS NEURONS AFFECTED BY FMR1 GENE MUTATION.耳鼻咽喉科,2014-02.
4Xueman Liu. Current trends in outcome studies for children with hearing loss and the need to establish a comprehensive framework of measuring outcomes in children with hearing loss in China.耳鼻咽喉科,2016-02.
5. local inhibition mediated byγ -aminobutyric acid-a receptor and duration tuning in inferior colliculus in guinea pigs.耳鼻咽喉科,2007-02.
6侯三林. Study：Portable Music Players Linked to Hearing Loss.教育学,2017-07.
7Daishi Chen;Ming Xu;Beibei Wu;Lei Chen. Histone deacetylases in hearing loss: Current perspectives for therapy.耳鼻咽喉科,2017-02.
8JI Fei LEI Lei ZHAO Su-ping LIU Ke-fang ZHOU Qi-you YANG Shi-ming. An investigation into hearing loss among patients of 50 years or older.耳鼻咽喉科,2011-01.
9Zhu Yuhua,Bing Dan,Wang Dayong,Zhao Lidong,Yin Zifang,Zhang Qiujing,Guan Jing,Wang Qiuju. Analysis of thyroid dysfunction in patients with sudden sensorineural hearing loss.医药卫生,2021-03.
10. sudden sensorineural hearing loss treated with intratympanic dexamethasone injection.耳鼻咽喉科,2010-01.

PERIPHERAL HEARING LOSS CAUSES HYPEREXCITABILITY OF THE INFERIOR COLLICULUS

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PERIPHERAL HEARING LOSS CAUSES HYPEREXCITABILITY OF THE INFERIOR COLLICULUS

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