Comparative Analysis of Protein-Protein Interactions in Cancer- Associated Genes-中国期刊网

摘要 Protein-proteininteractions(PPIs)havebeenwidelystudiedtounderstandthebiologicalprocessesormolecularfunctionsassociatedwithdifferentdiseasesystemslikecancer.Whilefocusedstudiesonindividualcancershavegeneratedvaluableinformation,globalandcomparativeanalysisofdatasetsfromdifferentcancertypeshasnotbeendone.Inthiswork,wecarriedoutbioinformaticanalysisofPPIscorrespondingtodifferentiallyexpressedgenesfrommicroarraysofvarioustumortissues(belongingtobladder,colon,kidneyandthyroidcancers)andcomparedtheirassociatedbiologicalprocessesandmolecularfunctions(basedonGeneOntologyterms).Weidentifiedasetofprocessesorfunctionsthatarecommontoallthesecancers,aswellasthosethatarespecifictoonlyoneorpartialcancertypes.Similarly,proteininteractionnetworksinnucleicacidmetabolismwerecomparedtoidentifythecommon/specificclustersofproteinsacrossdifferentcancertypes.Ourresultsprovideabasisforfurtherexperimentalinvestigationstostudyproteininteractionnetworksassociatedwithcancer.Themethodologydevelopedinthisworkcanalsobeappliedtostudysimilardiseasesystems.

1Mahmood A. Mahdavi Yen-Han Lin. Prediction of Protein-Protein Interactions Using Protein Signature Profiling.分子生物学,2007-03.
2Limin LI;Waiki CHING;Yatming CHAN;Hiroshi MAMITSUKA. ON NETWORK-BASED KERNEL METHODS FOR PROTEIN-PROTEIN INTERACTIONS WITH APPLICATIONS IN PROTEIN FUNCTIONS PREDICTION.系统科学,2010-05.
3Pengcheng Zhu;Haibin Gu;Yinming Jiao;Donglin Huang;Ming Chen. Computational Identification of Protein-Protein Interactions in Rice Based on the Predicted Rice Interactome Network.分子生物学,2011-04.
4LI Wenzhao;MENG Wei;TIAN Pu. Impact of Stable Protein-protein Interaction on Protein Conformational Space.化学,2015-01.
5Thanigaimani Rajarathinam Yen-Han Lin. Topological Properties of Protein-Protein and Metabolic Interaction Networks of Drosophila melanogaster.分子生物学,2006-02.
6YURYEVANTON LAWRENCEPWENNOGLE. The RAF family：an expanding network of post—traslational controls and protein—protein interactions.细胞生物学,1998-02.
7Li-Xia Huang Yan-Jun Gong Jun Gu Bao-Juan Zeng Li-Hua Huang Qi-Li Feng. Expression, subcellular localization and protein-protein interaction of four isoforms of EcR/USP in the common cutworm.昆虫学,2015-01.
8Wanfei Liu;Dawei Huang;Kan Liu;Songnian Hu;Jun Yu;Gang Gao;Shuhui Song. Discovery,Identification and Comparative Analysis of Non-Specific Lipid Transfer Protein （nsLtp） Family in Solanaceae.分子生物学,2010-04.
9宋波;王波;崔晓楠;李晓枫;周春辉;侯力;唐建武. COMPARATIVE ANALYSIS OF LYMPHATIC METASTASIS——ASSOCIATED GENES IN MOUSE HEPATOCELLULAR CARCINOMA CELL LINES WITH DIFFERENT METASTATIC POTENTIAL.肿瘤,2006-01.
10JiaoJin. Identification of Protein Coding Regions of Rice Genes Using Alternative Spectral Rotation Measure and Linear Discriminant Analysis.分子生物学,2004-03.

Comparative Analysis of Protein-Protein Interactions in Cancer- Associated Genes

来源期刊

相关推荐

同分类资源更多

相关关键词

Comparative Analysis of Protein-Protein Interactions in Cancer- Associated Genes

来源期刊

相关推荐

同分类资源 更多

相关关键词

同分类资源更多