Buyang Huanwu decoction increases vascular endothelial growth factor expression and promotes angiogenesis in a rat model of local cerebral ischemia-中国期刊网

摘要 Angiogenesisintheinfarctperipherycanimprovebloodflow.Vascularendothelialgrowthfactor(VEGF)hasbeenconsideredapotentialtherapeutictargetforstroke.BuyangHuanwudecoction(BYHWD)isaclassictraditionalformulaintraditionalChinesemedicineandisusedtotreatstroke;inaddition,thepromotioneffectsonVEGFproteinexpressionhavebeenconfirmed.However,littleisknownabouthowBYHWDregulatesangiogenesis,orabouttheeffectsofBYHWDonVEGFmRNAexpression.Forthisreason,thepresentstudymeasuredmicrovesseldensityinratswithcerebralischemiausingimmunohistochemistry.Inaddition,VEGFexpressionwasmeasuredbyreverse-transcriptionpolymerasechainreactionandenzyme-linkedimmunosorbentassaytode-terminetheeffectsofBYHWDonangiogenesisandVEGFexpressioninratswithcerebralischemia.Resultsdemonstratedthatmicrovesseldensity,aswellasVEGFmRNAandproteinexpression,increasedafter7and14daysofBYHWDtreatment,whichsuggeststhatBYHWDpromotedan-giogenesisfollowingcerebralischemiaandupregulatedVEGFmRNAandproteinexpressioninischemiccerebralregions.

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Buyang Huanwu decoction increases vascular endothelial growth factor expression and promotes angiogenesis in a rat model of local cerebral ischemia

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Buyang Huanwu decoction increases vascular endothelial growth factor expression and promotes angiogenesis in a rat model of local cerebral ischemia

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