简介：AhybridGA(geneticalgorithm)-basedclustering(HGACLUS)schema,combiningmeritsoftheSimulatedAnnealing,wasdescribedforfindinganoptimalornear-optimalsetofmedoids.Thisschemamaximizedtheclusteringsuccessbyachievinginternalclustercohesionandexternalclusterisolation.TheperformanceofHGACLUSandothermethodswascomparedbyusingsimulateddataandopenmicroarraygene-expressiondatasets.HGACLUSwasgenerallyfoundtobemoreaccurateandrobustthanothermethodsdiscussedinthispaperbytheexactvalidationstrategyandtheexplicitclusternumber.
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