简介：Si-Miao-Wan(SMW),atradiationalChinesemedicinalformulaconsistingofAtractylodisRhizoma,PhellodendriChinensisCortex,CoicisSemen,andAchyranthisBidentataeRadix,hasbeenusedforthetreatmentofgoutandgoutyarthritisformanyyears.Inthepresentstudy,aliquidchromatographyquadrupole-time-of-flightmassspectrometry(LC-Q-TOF/MS)methodwasestablishedtoidentifythemultipleconstituentsofSMWanditsmetabolitesinratbiologicalsamplesafteroraladministration.Atotalof48compoundsinSMW,including21alkaloids,12organicacids,2terpenes,3lactones,2phytosterols,and8othercompounds,weretentativelycharacterizedwiththediagnostic-ionfilteringstrategy.BasedonthediagnosticionsappliedtoidentifycompoundsinSMW,28prototypecompoundsand10metaboliccompoundsweredetectedinthebiologicalsamples.ThiswasthefirstcomprehensivedrugmetabolisminvestigationofSMWinrats.Thedevelopedmethodcouldbeausefulmeansforidentifyingthemulti-componentsinSMWandthemetaboliccomponents.TheresultsmayhelpexplorethepossiblemetabolicprocessesandmechanismofactionforSMWinvivo.

简介：目的:探讨针刀术配合金药膏治疗肩周炎的疗效。方法:肩周炎患者患者100例随机均分为推拿组与针刀组,各50例,推拿组行舒筋汤配合推拿疗法,针刀组在推拿组基础上行针刀术配合金药膏治疗,对比观察两组治疗效果。结果:针刀配合金药膏组患者50例中治疗后1个月治疗效果显著优于推拿组。结论:针刀术治疗肩周炎具有微创、痛苦小、定位精确、方法简便、见效快等特点,配合使用金药膏治疗,能够活血化瘀,大大提高了肩周炎治愈的临床效果。