简介：Humanp100proteinconsistsoffourrepeateddomainsofstaphylococcalnuclease(SN)-likedomain,aswellasatudor(TD)domainthereafter.WehavepreviouslyshownthattheSN-likedomainofp100interactedwithSTAT6andthelargesubunitofRNApolII,resultingintheenhancementofSTAT6-mediatedgenetranscriptionalactivation.Here,weshowthatSN-likedomainalsointeractedwithCREBbindingprotein(CBP)anddirectlyenhancedtheacetyltransferaseactivityofCBPonhistone.Ontheotherhand,overexpressionofCBPalonehadnoabilitytosignificantlyincreaseSTAT6dependenttranscriptionalactivation,however,togetherwithp100protein,sufficientlyenhancedtheactivationoftranscriptionwhichwasinlinewiththepreviousresultthatp100proteinbridgedSTAT6withCBP.