简介：Peptidenucleicacid(PNA)isaDNAmimicthatwasoriginallydevelopedbyPeterENielsenin1991asareagentforsequence-specificrecognitionofdoublestranded(ds)DNAbyaconventionaltriplehelixtypeprinciple.

简介：INTRODUCTIONCalciumphosphatecements(CPC)overcomethepracticaldisadvantagesofblocksorgranuleslcanbehandledasapasteandsitinsitu.TheirstructureandcompositionclosetothatofHAPmakethembiocompatiblematerials.2Theconventionalcalciumphosphatecementhadsomeproblemssuchaslongsettingtime(30～60min)andlowcompressivestrength,etc.Inoursystem,anα-TCP/TTCPpowdermixturewasmixedwithwatercontainingcitricacidtocontrolthesettingtimeandcompressivestrength.Inthispaper,theeffectsofvariousconcentrationcitricacidsolutionsonthepropertiesofthecementarereported.

简介：客观:cross-linked生产，它被准备由哈并且cross-linking代理人STMP，EDC，通过cross-linking反应的GP，可能在药交货系统(DDS)被使用。保证临床的申请的安全，优秀性质象没有房间毒性那样，nonirritant，没有将军毒性，没有免疫学的拒绝是必要的。方法:根据GB/T的请求，16886.1在医药biomaterials，房间毒性测试，溶血测试，intracutaneous刺激测试，尖锐毒性测试，和过分敏感的测试的安全评估上被要求。结果：HA-STMP的房间毒性，HA-EDC，HA-GP都是不到1。所有过分敏感的测试是合格的。但是HA-EDC，忽视的生产的不同的度激动的HA-GP，细微毒性，溶血率，它比标准价值大。结论:HA-STMP拥有赞成biocompatibility，它是一种理想的biomaterials和药搬运人。

简介：Skiniscomposedofbothadermallayer-consistingprimarilyoffibroblasts,andmatrixmacromolecules(ECM)-andanepidermallayer-composingofepidermalcellscontainingkeratinfilamentsundergoingprogressivedifferentiationfromabasalproliferatinglayertoasurfaceconsistingofterminallydifferentiated,epidermalcellsthatprotecttheskinfromtheenvironment.

简介：Thefutureofingestiblesensorscouldbeacrossbetweensilicon-basedcircuitryandbiodegradablematerials,withbatteriesmadeofnutrientsandrunningonstomachjuices.Ingestiblesensorscouldprovideagutcheckforearlysignsonbacterialinfection,lookforsymptomsofgastrointestinaldisorderssuchasCrohn'sDisease,monitoruptakeofmedications,andevenstudythe

简介：Thisresearchusesalginateandhyaluronicacidasthemaincomponenttopreparesupport,thenexploresthepossibilitiesasatissueengineeringscaffold.Firstly,prepareHAwithvariousaveragemolecularweightandalginatewithdifferentviscosity,mixthemupatacertainproportionandmakeitintoaAlgCa2+-HAcompositescaffoldwithafilm-formingmethod.Thisarticlediscussesthefeasibilityofthisscaffoldusedintissueengineeringfieldaccordingtotheconsequenceofmoisturecontenttesting,mechanicalanalysis,andscanningelectronmicroscopyanalysis.ThestructureandpropertiesofAlgCa2+-HAcompositescaffoldarecloselyrelatedtosomefactorssuchasaveragemolecularweightofhyaluronicacid,hyaluronicacidconcentration,alginateviscosity,cross-linkingagentsandprocessingtechnology.TheAlgCa2+-HAcompositematerial,whichisatdifferentproportionsandaddingdifferentcross-linkingagent,hassomecertaincharacteristics:moisturecontentrangingfrom50%to95%,tensilestrengthbetween2.69N/mm2and4.299N/mm2,andelongationatbreakisabout58%to160%.ThepreparedAlgCa2+-HAcompositescaffoldscanbeusedastissueengineeringscaffoldsresultingfromitshighmoisturecontent,goodmechanicalpropertiesandidealporestructure.更多还原

简介：Thecruxoftissueengineeringistoconstructhighlyporousthree-dimensionalscaffoldwithdesiredcellsonit.Becausethescaffoldservesasbothaphysicalsupportandanadhesivesubstrateforisolatedcellsduringinvitrocultureandsubsequentimplantation,thematerialsforscaffoldshouldbenon-toxicandbiocompatible,highlyporousandprocessableintodevicesofvariousshapes.

简介：客观：击倒链球菌mutans(S.mutans)的全部勒克司基因经由相应再结合和构造的UA159紧张S的删除勒克司的变异的紧张。Mutans。学习S的酸抵抗之间的差别。MutansIngbrittC国际标准紧张和勒克司变异的紧张的酸抵抗。方法：二DNA碎裂定位在勒克司上面、下游基因被放大，在他们之间的PJT10的抗生素的一种抵抗基因被设计进PUC19为构造再结合的plasmidplasmidpUCluxKO。S.mutans房间与的ElectrotransformationpUCluxKO变异导致了抗生素的一种的隔离抵抗S。Mutanstransformants，它被聚合酶链反应，V.harveyiBB170光生物鉴定和定序的分析识别。S的答案。有一样的密度的Mutans标准紧张和勒克司变异的紧张被做并且在pH有教养为一样的period.Terminal生长状况的3.5～7.0BHI液体compared.Firstly在pH被酸化5.5BHI液体，二紧张在pH是有教养的3.0BHI液体。二紧张的酸忍耐回答是compared.Results:限制endonuclease分析证明那pUCluxKO变异的向量成功地被重新结合。S.mutans异种的删除勒克司的地位被PCR与为勒克司和抗生素的一种抵抗的基因特定的教材证实。S.mutans异种不能导致生物体之发光，indiating异种成功地被重新结合。在文化的二十代以后，构造中国S.mutans异种被证实稳定。aciduricity的重要差别在S.mutans标准紧张和标准紧张的抵抗是的勒克司变异的strain.The酸之间被观察比二紧张两个都显示了的勒克司变异的strain.The的强壮酸忍耐回答的能力。结论:S.mutans基因突变而产生之遗传的交换plasmid校正地被构造并且一S.mutans的勒克司否定的异种被构造，它能帮助推进在S.mutans的致病学习勒克司的角色。勒克司变异的紧张对酸忍耐回答的酸inactivation，而是能力更敏感仍然存在。

简介：Oneofthechallengesinthefieldoftissueengineeringisthedevelopmentofbiomaterial/cellinteractions.Forthispurpose,theuseofbiologicalmaterialsintissueengineeringrequirestheapplicationofdifferentchemicalorphysicalproceduresforsurfacemodificationinordertoimprovethecellaffinityofbiomaterials.Wehavestudiedtheeffectsofonechemicaltreatmentandonephysicaltreatment:1-(3-dimethylaminopropyl)-3-ethylcarbodiimide(WSC)andentrapment.