简介：Severeacuterespiratorysyndrome(SARS)isaseriousandfatalinfectiousdiseasecausedbySARScoronavirus(SARS-Cov),anovelhumancoronavirus.SARS-Covinfectionstimulatescytokines(e.g.,IL-10,IFN-γ,IL-1,etc.)expressiondramatically,andTlymphocytesandtheirsubsetsCD4+andCD8+Tcellsaredecreasedafteronsetofthedisease.SARS-specificIgGantibodyisgeneratedinthesecondweekandpersistsforalongtime,whereasIgMisexpressedtransiently.ThespikeproteinandneucleocapsidproteinaremostabundantinSARS-Covandcontributedominantlytotheantibodyproductionduringthecourseofdisease.Spikeprotein,especiallytheACE-2bindingregion(318-510aa)iscapableofproducingneutralizingantibodytoSARS-Cov.NeucleocapsidproteininducesprotectivespecificCTLtoSARS-Cov.Therefore,applicationswithspikesubunit,neucleocapsidsubunitaswellasinactivatedSARS-CovarethreeprospectivevaccinationstrategiesforSARS.

简介：T盒子抄写因素T赌注(Tbx21)作为类型1-like免疫的一个关键管理者出现了，起在在T和B淋巴细胞，以及树枝状的房间和自然漂亮房间的受动器房间命运的建立或维护的关键作用。几自体免疫的疾病，特别古典主义地与T助手1有关考虑的那些(Th1)免疫，看起来要求T赌注，至少是在老鼠模型判定了。这评论在autoimmunity在免疫，以及它的重要性总结T-bet的角色的当前的理解，与为治疗学的干预的含意。

简介：Thenuclearreceptorsuperfamilyandthetranscriptionalfactorsassociatedwithcytokinesareinherentlydifferentfamiliesofsignalingmoleculesandactivategenetranscriptionbybindingtotheirrespectiveresponsiveelement.However,ithasbecomeincreasinglyclearfromourworksandothersthatnuclearreceptorsareimportantregulatorsofcytokineproductionandfunctionthroughcomplexandvariedinteractionsbetweenthesedistincttranscriptionalfactors.Thisreviewprovidesageneraloverviewofthemechanismofactionofnuclearreceptorsandtheirtranscriptionalcrosstalkwithtranscriptionalfactorsassociatedwithcytokinetransductionpathways.Oneofthemostimportantmechanisticaspectsisproteintoproteininteractionthroughadirectorco-regulator-mediatedindirectmanner.Suchcrosstalkiscruciallyinvolvedinphysiologicalandtherapeuticrolesofnuclearreceptorsandtheirligandsinimmunity,inflammationandcytokine-relatedtumors.Cellular&MolecularImmunology.2004;1(6):416-424.

简介：Specificcellularimmunetolerancemaybeessentialforsuccessfulxenotransplantationinhumans.Thymectomized(ATX),TandNKcell-depletedimmunocompetentmicegraftedwithxenogeneicfetalpigthymicandlivertissue(FPTHY/LIV)resultinefficientmousethymopoiesisandperipheralrepopulationoffunctionalmouseCD4+Tcell.Veryimportantly,thereconstitutedmouseTcellsarespecificallytoleranttopigdonorantigens.StudiesdemonstratedthatporcineMHCsmediatedpositiveandnegativeselectionofmousethymocytesinFPTHYgrafts,whereasmouseMHCswereinvolvedinnegativeselectioningrafts.Therefore,Tcelltolerancetoxenogeneicdonorantigenscouldbeinducedbygraftingdonorthymustissue.XenogeneicthymicreplacementmighthaveapotentialroleinthereconstitutionofcellularimmunityinpatientswithAIDSorotherimmunodeficienciescausedbythymusdysfunction.