简介：backgroundStudieshavebeeninconsistentregardingwhetherhyperuricemia,eitherdiuretic-ornondiuretic-induced,isanindependentriskfactorforcardiovascularevents.Thestudyinvestigatedtheassociationofcardiovasculardiseasewithdiuretic-andnondiuretic-inducedelevatedserumuricacid.MethodsAcommunity-basedcross-sectionstudywasconductedin5,235treatedanduntreatedhypertensivepatientsaged40-75years.Conventionalriskfactors,serumuricacidandthepresenceofcardiovasculardiseaseweredetermined.Hyperuricemiawasdefinedasserumuricacidlevels≥420μmol/Linmenor≥360μmol/Linwomen.ResultsHyperuricemiawasmorecommoninmenthaninwomen(21.5%vs.10.2%,P<0.001).Afteradjustmentforageandotherconventionalriskfactors,hyperuricemiawasassociatedwithmetabolicsyndrome,decreasedcreatinineclearance,anduseofdiureticsinbothgenders,aswellasageinwomenandalcoholconsumptioninmen.Thepresenceofcoronaryarterydiseaseorstrokeincreasedsignificantlywiththeincreaseofquartilesofserumuricacid(8.0%,11.0%,13.4%,and16.8%,respectively,P<0.01),andthehighestserumuricacidquartilewasassociatedwitha1.8-foldriskforcardiovasculardisease(OR:1.83,95%CI:1.24-2.71)inuntreatedwomen.Butthisassociationwasnotobservedinuntreatedmenaswellasintreatedpatientsusingdiureticsinbothgenders.ConclusionsHyperuricemiaismarkedlyassociatedwithmetabolicsyndrome,decreasedcreatinineclearance,useofdiureticsbesidesalcoholconsumptioninmenandageinwomen.Elevatedserumuricacid,butnotthatdiuretic-induced,maybeassociatedwithincreasedtheriskofcardiovasculardiseaseinuntreatedhypertensivewomen.