简介：ChildsNervSyst.2008Jun18.OBJECTIVES:Despiterevolutionarytechnicaladvancementinneuroimagingandoperativeneurosurgery,surgicalextirpationoffocalbrainstemglioma(BSG)remainssteepedincontroversy.Inthisstudy,weevaluatedourseniorauthor's(CT)surgical

简介：Objective:Theaimofthepresentstudywastoconstructariskassessmentmodelwhichwastestedbydisease-freesurvival(DFS)ofesophagealcancerafterradicalsurgery.Methods:Atotalof164consecutiveesophagealcancerpatientswhohadundergoneradicalsurgerybetweenJanuary2005andDecember2006wereretrospectivelyanalyzed.Thecutpointofvalueatrisk(VaR)wasinferredbystem-and-leafplot,aswellasbyindependent-samplest-testforrecurrence-freetime,furtherconfirmedbycrosstabchi-squaretest,univariateanalysisandCoxregressionanalysisforDFS.Results:ThecutpointofVaRwas0.3onthebasisofourmodel.Therateofrecurrencewas30.3%(30/99)and52.3%(34/65)inVaR<0.3andVaR≥0.3(chi-squaretest,χ2=7.984,P=0.005),respectively.The1-,3-,and5-yearDFSofesophagealcancerafterradicalsurgerywas70.4%,48.7%,and45.3%,respectivelyinVaR≥0.3,whereas91.5%,75.8%,and67.3%,respectivelyinVaR<0.3(Log-ranktest,χ2=9.59,P=0.0020),andfurtherconfirmedbyCoxregressionanalysis[hazardratio=2.10,95%confidenceinterval(CI):1.2649-3.4751;P=0.0041].Conclusions:Themodelcouldbeappliedforintegratedassessmentofrecurrenceriskafterradicalsurgeryforesophagealcancer.

简介：ＴＨＥＤＩＡＧＮＯＳＩＳＡＮＤＴＲＥＡＴＭＥＮＴＦＯＲＲＥＣＵＲＲＥＮＴＤＹＳＰＨＡＧＩＡＯＦＥＳＯＰＨＡＧＥＡＬＣＡＲＣＩＮＯＭＡＡＦＴＥＲＲＡＤＩＣＡＬＲＡＤＩＯＴＨＥＲＡＰＹＣｈｅｎＫｅｎｅｎｇ陈克能ＣｈｅｎｇＢａｎｇｃｈａｎｇ程邦昌Ｄｅｐａ...

简介：Objective:ToassesstheeffectofantiviraltherapyforhepatitisBvirus(HBV)-relatedhepatocellularcarcinoma(HCC)afterradicalhepatectomy.Methods:Atotalof478HBV-relatedHCCpatientstreatedbyradicalhepatectomywereretrospectivelycollected.Patientsinthetreatmentgroup(n=141)receivedpostoperativelamivudinetreatment(100mg/d),whereaspatientsinthecontrolgroup(n=337)didnot.Recurrence-freesurvival(RFS)rates,overallsurvival(OS)rates,treatmentsforrecurrentHCCandcauseofdeathwerecomparedbetweenthetwogroups.Propensityscorematching(PSM)analysiswasalsoconductedtoreduceconfoundingbiasbetweenthetwogroups.Results:The1-,3-,and5-yearRFSratesdidn’tsignificantlydifferbetweenthetwogroups(P=0.778);however,the1-,3-,and5-yearOSratesinthetreatmentgroupweresignificantlyhigherthanthoseinthecontrolgroup(P=0.002).Similarresultswereobservedinthematcheddata.SubgroupanalysisshowedthatantiviraltreatmentconferredasignificantsurvivalbenefitforBarcelonaClinicalLiverCancerstageA/Bpatients.FollowingHCCrecurrence,morepeopleinthetreatmentgroupwereabletochoosecurativetreatmentsthanthoseinthecontrolgroup(P=0.031).Forcauseofdeath,fewerpeopleinthetreatmentgroupdiedofliverfailurethanthoseinthecontrolgroup(P=0.041).Conclusion:PostoperativeantiviraltherapyincreaseschancesofreceivingcurativetreatmentsforrecurrentHCCandpreventsdeathbecauseofliverfailure,therebysignificantlyprolongingOS,especiallyinearly-orintermedian-stagetumors.

简介：Objective:ToinvestigatewhetherGli1expressionisimportantinrelapseafterradicaloperationofbreastcancer.Methods:Usingimmunohistochemistry,Gli1expressionwasanalyzedinhumanprimarybreastcancer(n=284)andparacanceroustissues(n=20),andalsoinlocallymphnodes(n=28)andmetastaticlymphnodes(n=28).Results:InitialanalysisofGli1expressioninasmallcohortof20breasttumorsandtheirparacanceroustissuesshowedatendencytowardsGli1overexpressioninbreastcancertissues(P<0.001).Further,Gli1expressionin284breastcancertissuesampleswasanalyzedandasignificantcorrelationwasfoundbetweenincreasedexpressionofnuclearGli1andunfavorablerecurrence-freesurvival(RFS)(P<0.05).ThenuclearexpressionofGli1inmetastaticlymphnodesfollowingrelapseafterradicaloperationwasmuchhigherthanthatinthelocallymphnodesofprimarycarcinoma(P<0.05).Mostinterestingly,theexpressionofGli1wasmuchhigherintheinterstitialtissuesoftherelapsedgroupthanofthenon-relapsedgroup(P<0.001).Conclusions:BreastcancershowsahighprevalenceofGli1expression,whichissignificantlycorrelatedwithaggressivefeaturesandunfavorableRFS.NuclearGli1overexpression,especiallyintheinterstitialtissues,signifiedearlyrelapseafterradicaloperationofbreastcancer.

简介：Objective:Theaimofthisstudywastoinvestigatethefeasibilityofusingultrasonicscalpelcombinedwithvascularclipinparametrialmanagement,calledlimitedenergyparametrialresection/dissection(LEPRD),inlaparoscopicnerveplane-sparingradicalhysterectomy(NPSRH),amodifiednerve-sparingradicalhysterectomy(NSRH);andtoevaluateitseffectivenessinpelvicautonomicnervepreservation.Methods:FromJuly2012toJanuary2016,257consecutivepatientswithstageIB1toIIA2cervicalcancerwhounderwentNPSRHwereincludedinthisstudy.Patientsweredividedintothreecohortsaccordingtothedifferentparametrialresectionmodality.Theclinical,pathologicalandsurgery-relatedparameterswerecomparedbetweenthethreegroups.Short-andlong-termpostoperativebladderfunctionswereevaluated.Results:LEPRDwasattemptedin94patients,andwassuccessfulin65(69.1%)patients(LEPRDgroup).Theremaining29(30.9%)patientsrequiredbipolarcoagulationafterfailureofvascularclipping(combinedmodalitygroup).Routinebipolarcauterywasusedintheother163patientsduringtheparametrialresection(bipolargroup).ThebloodlossintheLEPRDgroupwassignificantlylowerthanthoseintheothertwogroups(P<0.001).TherateofsuccessfulFoleyremovalonpostoperativeday7wassignificantlyhigherintheLEPRDgroupthaninthebipolargroup(P=0.022).TheincidenceofchronicvoidingdysfunctionwassignificantlylowerintheLEPRDgroupthaninthebipolargroup(P=0.019).Conclusions:ItisfeasibletoperformLEPRDinNPSRHforcervicalcancers.Thiskindoflimitedenergysurgicaltechniqueisassociatedwithlessbloodloss,andleadstoimprovedpostoperativebladderfunction.

简介：FromJanuary1989toJuly1992,70patientsAcceptedforpublication.October23,1998CorrespondencetofXUGuang-chuan;DepartmentofOncology,TumorHospital,SunYat-SenUniversityofMedicalSciences,No.651,DongFengEastRoad,Guangzhou510060,China,Faxf(0086-20)-87761547;Phon...