简介:Drugscancauseobviousdamagetothebrain.Toverifytherelationshipbetweenacupuncture,neurotrophicfactorexpressionandbraincellstructuralchanges,thisstudyestablishedaratmodelofheroinrelapseusingintramuscularinjectionofincreasingamountsofheroin.Duringthedetoxificationperiod,ratmodelsreceivedacupunctureatBaihui(DU20)andDazhui(DU14).Electronmicroscopydemonstratedthatthestructureoftheventraltegmentalareainheroinrelapseratsgraduallybecamenormalizedafteracupuncturetreatment.Immunohistochemicalstainingexhibitedthattheexpressionofbrain-derivedneurotrophicfactorandglialcellline-derivedneurotrophicfactorincreasedintheventraltegmentalareafollowingacupuncture.Moreover,theeffectsweresimilartothatofmethadone,atypeofmedicinecalledanopioid.ResultssuggestedthatacupunctureatBaihuiandDazhuiprotectedbrainneuronsagainstinjuryinratswithheroinrelapsebypromotingbrain-derivedneurotrophicfactorandglialcellline-derivedneurotrophicfactorexpression.
简介:Despitetheadvancesincombinatorialorsyntheticchemistryandbioinformatics,recentliteraturehasdemonstratedtherelevanceofnatureandbiomassasasourceofnewmoleculestotreatdifferentpathologies,i.e.,bioactivecompoundsobtainedfromEcteinascidiaturbinatetotreatsometypesofcancerorrapamycinfromStreptomyceshygroscopicustopreventorganrejectionaftertransplant.Thistrend