简介：Amathematicalmodelhasbeenformulatedinaccordancewithcellchemotaxisandrelevantexperimentaldata.Athree-dimensionallatticeBoltzmannmethodwasusedfornumericalsimulation.Thepresentstudyobservedtheeffectsofglialscarsizeandinhibitorconcentrationonregenerativeaxonalgrowthfollowingspinalcordtransection.Thesimulationtestcomprisedtwoparts:(1)whenreleaseratesofgrowthinhibitorandpromoterwereconstant,theeffectsofglialscarsizeonaxonalgrowthratewereanalyzed,andconcentrationsofinhibitorandpromoterslocatedatthemovinggrowthconeswererecorded.(2)Whentheglialscarsizewasconstant,theeffectsofinhibitorandpromoterreleaseratesonaxonalgrowthratewereanalyzed,andinhibitorandpromoterconcentrationsatthemovinggrowthconeswererecorded.Resultsdemonstratedthat(1)alargerglialscarandahigherreleaserateofinhibitorresultedinareducedaxonalgrowthrate.(2)Theaxonalgrowthratedependedontheratioofinhibitortopromoterconcentrationsatthegrowthcones.Whentheaverageratiowas<1.5,regeneratingaxonswereabletogrowandsuccessfullycontacttargetcells.

简介：NewZealandrabbitswererandomlydividedintoanischemiagroup(occlusionoftheabdominalaortafor60minutes),anischemia-reperfusiongroup(occlusionoftheabdominalaortafor60minutesfollowedby48hoursofreperfusion)andasham-surgerygroup.Two-dimensionalgelelectrophoresisdetected49differentiallyexpressedproteinsinspinalcordtissuefromtheischemiaandischemia/reperfusiongroupsand23ofthemwereidentifiedbymassspectrometry.Intheischemiagroup,theexpressionofeightproteinswasupregulated,andthatoftheremainingfourproteinswasdownregulated.Intheischemia/reperfusiongroup,theexpressionoffourproteinswasupregulated,andthatoftwoproteinswasdownregulated.Inthesham-surgerygroup,onlyoneproteinwasdetected.Intheischemiaandischemia/reperfusiongroups,fourproteinsoverlappedbetweengroupswiththesamedifferentialexpression,includingthreethatwereupregulatedandonedownregulated.Theseproteinswererelatedtoenergymetabolism,celldefense,inflammatorymechanismandcellsignaling.