简介：AIM:Toexaminethemechanismofthedevelopmentofpseudoexfoliation(PSX)syndromeviabothcytokineformationandendothelialvasorelaxingandgrowthfactorsthatwillprovideusnewtherapeuticinsightsforthetreatment.METHODS:Thisisacrosssectionalstudyincludedtwogroups;Group1:controlpatientswithnuclearcataract(n=20,aged51-80years).Group2:PSXpatientswithnuclearcataract(n=18,aged50-90years).Patientswithotherophthalmicproblemsandsystemicdiseaseswereexcluded.Vascularendothelialgrowthfactor(VEGF),interleukin-6(IL-6)andinterleukin-1β(IL-1β)andnitrotyrosinelevelsweredeterminedthroughserumsamplesbyEnzyme-linkedimmunosorbentassay(ELISA)method.Nitrite-nitratelevelsweremeasuredwithphotometricendpointdetermination.RESULTS:Therewerenosignificantdifferencesbetweenthegroupsintermsofage,VEGF,IL-1β,nitrite-nitrateandnitrotyrosine.ThesignificantresultswerethemeanIL-6levelsthatwerehigherinPSXgroup2(37.68±29.52pg/mL)comparedtothatincontrolgroup1(15.32±10.08pg/mL)(P<0.001).CONCLUSION:SeveralinteractingandextendingbiochemicalpathwaysmayleadtothepromotionofVEGFandIL-6expressions.IL-6whichistheonlyalteredmarkerinourstudymayindirectlycauseanincreaseofvascularpermeabilityandneovascularization.WesuggestinflammationasafactorthatcanbeinvolvedinetiopathogenesisofPSX.

简介：目的探讨医院及家庭联合治疗大龄儿童弱视的临床效果。方法选择7～15岁的大龄儿童73例（113眼），采用医院及家庭联合实施弱视综合疗法对患儿进行治疗，并对临床资料进行总结、分析。结果113眼中有96眼有效，总有效率84．96％，其中基本痊愈61眼（53．98％）、进步35眼（30．97％）、无效17眼（15．93％）。17例无效眼中，屈光度超过±10．00D者6眼、斜视伴双眼无同视功能5眼、眼颤者1眼、散光超过4．00D者2眼、家庭不配合未坚持治疗者3眼。轻、中度弱视的疗效优于重度弱视；中心注视的疗效优于旁中心注视。结论医院及家庭联合治疗大龄儿童弱视能取得满意疗效，需要医务人员、家属和儿童的共同配合。只有充分调动弱视患儿成长环境中关系密切的群体力量，才能提高其治疗效果。因此对大龄儿童的弱视治疗，除科学、系统及规范的治疗外，还应积极地提高家庭支持度。

简介：AIM:Topresentretinalmicrostructure,metabolismandfunctionabnormalitiesinthecourseofmultipleevanescentwhitedotsyndrome(MEWDS)byHeidelbergspectralismodalityimagingplatformandobserveitsoutcomebyEDI-SD-OCTandtwowavelengthautofluorescence.METHODS:Acaseofmultipleevanescentwhitedotsyndromeina23-year-oldfemalepresentedinitiallywitha15-dayhistoryoffloatersandacentralscotomaintherighteye.Toestablishthediagnosis,multimodalityimagingwasperformed,namely,bluelight-fundusautofluorescence(BL-FAF,excitation488nm,emission>500nm),near-infraredfundusautofluorescence(NIR-FAF,excitation787nm,emission>800nm)usingaconfocalscanninglaserophthalmoscope,fundusfluoresceinangiography(FFA),indocyaninegreenangiography(ICGA),spectrum-domainenhancedepthimagingopticalcoherencetomography(SD-EDI-OCT),multifocalelectroretinography(mf-ERG)andfundusphotograghwereperformedandfollowedupattheeighthmonthafterinitiallyvisiting.RESULTS:Opticalcoherencetomography(OCT)showedatransientdisruptionofthefovealphotoreceptoroutersegmentsincorrespondencetofovealgranularity.NIR-FAFshowedhypoautofluorescentareas,≤40μminsize,mostlyconcentratedaroundtheposteriorpoleanditstemporalsidelessthanthatinBL-FAF.Mf-ERGshowpinnacledisappearedinfoveaandmaculaandresponsesdecreasedmarkedlycomparedwiththefolloweye.Attheeighthmonthfollowup,hyperfluorescenceinBL-FAFweredisappear,while,NIR-FAFHypofluorescentspotsinearlystageofsuchlesionwerereduced.ButOCTdemonstratedthestructurewasrecoveredinresidualHypofluorescentareainNIR-FAF.Thesubfovealchoroidalthicknesswasdecreasedfrom372μmto307μmslightlyandcostlinewasrecovered.CONCLUSION:MEWDSisabenignself-healingdiseaseandthereisnopathologicalevidencetoinvestigatethenaturalcourseofsuchdisease.SD-OCTallowshighlydetailedimagesapproachinghistopathologytocertifythemicrostructura

简介：目的探讨对糖尿病视网膜病变出院患者进行护理指导的作用。方法将96例糖尿病视网膜病变出院患者分为观察组和对照组,各48例。观察组有计划的进行电话回访;对照组出院前做好出院指导。回访后12个月对两组进行问卷调查。结果经过电话回访式护理指导的患者家庭护理质量高于对照组,差异具有统计学意义（P〈0.05）。结论电话回访式健康教育有助于改变糖尿病视网膜病变出院患者的行为方式,控制血糖延缓糖尿病视网膜病变的进展。

简介：AIM:ToevaluatethecornealendothelialcelldensityandmorphologyinChinesepatientswithpseudoexfoliationsyndrome(PEX).·METHODS:Medicalrecordsof16patients(20eyes)withPEXwhopresentedtoourinstitutionbetweenJuly2008andJune2010wereretrospectivelyreviewed.Thirteeneyeshadcombinedglaucoma.Theinformationoffiveapparentlynormalfelloweyesinthesepatientswasalsorecorded.Lefteyesof20patientswithbilateralsenilecataractsbutnoothereyediseasewereincludedascontrols.Specularmicroscopywasperformedinalleyestoanalyzeforcornealendothelialcelldensityandmorphology.Celldensity,coefficientofvariationincellsize,andpercentageofhexagonalcellsincornealendotheliumwereevaluated.·RESULTS:ThemeancornealendothelialcelldensityinthePEXeyeswas2298±239cells/mm2,significantlylowerthanthatinthecataracteyes(2652±18cells/mm2,P=0.026),buttherewerenosignificantdifferencesincoefficientofvariationofcellsizeandfrequencyofhexagonalitybetweenthesetwogroups.NosignificantdifferencesinthethreeparameterswerefoundbetweentheapparentlynormalfelloweyesandthePEXeyesorthecataracteyes,orbetweenthePEXeyeswithandwithoutglaucoma.·CONCLUSION:CornealendothelialcelldensitymaydecreaseinChinesepatientswithPEX.ThedevelopmentofglaucomainPEXeyesdoesnotseemtoberelatedwiththechangeincornealendothelialcelldensityormorphology.

简介：<正>在文献中对白内障手术和人工晶体(IOL)植入后的炎性反应、IOL前纤维样膜形成的机理及引起继发性青光眼的原因已有详细的报道,但未提及由纤维样膜堵塞房角并可引起难以降低的高眼压。1993年以来我科在白内障囊外摘除和人工晶体植入术后的病例中,先后观察到13眼因房角膜性堵塞引起的高眼压,它们的临床表现不同于通常白内

简介：目的探讨青光眼患者健康教育效果.方法将100例青光眼患者随机分为对照组和实验组,对照组采取传统的功能制护理模式,对病人实施常规护理；实验组患者在此基础上,针对患者疾病各个阶段,全程实施健康教育.结果实验组患者术后并发症及焦虑发生率明显低于对照组,对疾病知识知晓率和对护理工作满意度高于对照组.结论对青光眼患者实施全程健康教育能有效减轻患者焦虑情绪,提高护理工作满意度.

简介：<正>计算机技术的不断进步,促进了多媒体技术的崛起和飞速发展,其应用已遍及国民经济与社会生活的各个角落,正在对人类的生产方式、工作方式乃至生活方式带来巨大的变革。多媒体技术是以计算机为中心,把语音处理技术、图像处理技术、视听技术集成在一起,把语音信号,图象信号先通过模数转

简介：目的探讨视网膜脱离患者的健康教育形式。方法以视网膜脱离患者为教育对象，通过护士对患者入院时、手术前、手术后、出院后四个不同时期进行有目的、有计划、系统性的教育，使患者掌握健康知识，并使其行为向有利于健康的方向发展。结果视网膜脱离患者术后视力恢复均较满意，且治疗期间未发生并发症。结论健康教育的应用对视网膜脱离患者的康复起到了促进作用，提高了患者适应能力和生活质量，保证了手术的成功率，同时和患者建立了良好的护患关系。

简介：AIM:ToidentifythegeneticdefectinaChinesefamilywithbilateralprogressivechildhoodposteriorcataract.METHODS:Atwo-generationfamilywasrecruitedinthisstudy.Familyhistoryandclinicaldatawererecorded.AllreportedcandidategenesassociatedwithcongenitalposteriorcataractwerescreenedbydirectDNAsequencing.·RESULTS:Allaffectedindividualspresentedposterioropacitiesinthelens.Directsequencingofthecandidategenesshowedaheterozygousc.2668C>TvariationinEPHA2gene,whichresultedinthereplacementofargininebycysteineatcodon890(p.R890C).Thismutationwasfoundintwoaffectedindividuals,butwasnotobservedin200normalcontrols.·CONCLUSION:Wereportanovelmutation(p.R890C)intheEPHA2receptortyrosinekinasegene.ThefindingexpandsthemutationspectrumofEPHA2inassociationwithposteriorcataract.

简介：目的探讨健康教育路径的实施在青光眼手术患者中的作用.方法将64例均行小梁切除术的青光眼患者分成对照组和观察组,对照组实施常规健康教育,观察组实施路径化健康教育,采用问卷调查法调查比较两组健康教育效果、患者依从性及护理满意度.结果健康教育效果观察组各项指标均高于对照组,差异有统计学意义（P＜0.05）;观察组依从性明显好于对照组,护理满意度调查观察组各维度均高于对照组,差异有显著意义（P＜0.01）.结论健康教育路径的实施,使疾病健康教育工作程序化、标准化、具体化,健康教育效果更为明显,有助于患者获得良好疗效,提高患者满意度.

简介：马凡氏综合症是一种常染色体不完全外显性遗传病,临床表现多样,主要涉及心血管、骨骼和眼等系统,病死率高。对发病患者应加强健康教育、风险管理,积极治疗护理,给予心理支持。患者生育正常儿和患儿的几率各为50%,这就意味着提高正常儿出生率是医务人员为之奋斗的目标,也是马凡氏综合症患者的福音,所以,加强遗传学、优生优育教育将成为马凡氏综合症健康教育的新动向。