简介：AIM:Tocharacterizetemporalpatternofresolutionandrecurrenceofnaivechoroidalneovascularization(CNV)secondarytowetage-relatedmaculardegeneration(AMD)treatedwithintravitrealbevacizumabonasneededregimen,andtoanalyzebaselineriskfactorsforCNVresolutionorrecurrence.METHODS:Ninety-oneeyesof80patientswithnewlydiagnosedwetAMDwereretrospectivelystudied.Alleyesweretreatedwitharoundofthreemonthlyintravitrealbevacizumabinjections,followedbyoneadditional’bonus’injectionafterresolutionofCNVactivity.Duringfollow-up,eyesweremonitoredwithfluoresceinangiography,opticalcoherencetomography,andbest-correctedvisualacuity(BCVA).IncaseofrecurrencesofCNVactivity,eyeswereretreatedwithotherroundsofbevacizumabinjectionsfollowingthesametreatmentprotocol.RESULTS:Overamedianfollow-upof532d,themedianresolutiontimeofCNVactivityinthefirst,second,andthirdtreatmentroundwas98d,126d,and111d,respectively.Themedianrecurrencetimeforthethreeroundswas154d,126d,and151d,respectively.Nosignificantdifferenceinresolutiontime(P=0.09)orinrecurrencetime(P=0.11)wasdetectedamongtreatmentrounds.Age(P=0.0082)andlensstatus(P=0.035)werefoundtobeassociatedwithCNVresolution;forevery1-yearincreaseinagetherewas4%greaterchanceofCNVresolution;Phakiceyesdemonstrateda33%betterchancetoexperienceCNVresolutionthanpseudophakiceyes.ForCNVrecurrence,lensstatus(P=0.0009)andgender(P=0.0446)werefoundtobepredictive;pseudophakiceyeshada3.69-foldgreaterrisktoexperiencerecurrenceofCNVactivitycomparedtophakiceyes;maleshada2.19-foldgreaterrisktoexperiencerecurrenceofCNVactivitythanfemales.NosignificantBCVAchangesamongthreetreatmentroundswerenoted(P=0.56).CONCLUSION:ResolutiontimeandrecurrencetimeofCNVactivitywerenotsignificantlydifferentamongtreatmentrounds,suggestingabsenceoftachyphylaxistobevacizumab.Acautiousdecisionshouldbemadeupondisco

简介：出版物号ISSN1673—3835，CN34—1292／R，本刊为季刊，A4国际开本48页，铜版纸印刷，照相图随文印刷。本刊的办刊宗旨为贯彻党和国家的防盲治盲工作方针，反映我国防盲治盲的现状和进展，传播国内外防盲治盲科技信息，推广防盲新技术，开展学术讨论和经验交流，促进我国防盲治盲工作，提高防盲治盲技术水平。

简介：目的评价甲基纤维素联合透明质酸钠制作软壳技术在白内障小切口非超声乳化手术中的效果.方法白内障“复明工程”患者261例295眼.随机分为A、B两组,其中A组术中单用透明质酸钠,B组术中联合使用甲基纤维素和透明质酸钠.手术方法为小切口非超声乳化加人工晶体植入.结果术后第ld裸眼视力大于0.3者,A组78.79％（104/132）,B组87.1％（142/163）,两组之间差异显著（P＜0.05）；术后第7d视力在0.3以上者,A组93.9％（124/132）,B组94.5％（154/163）.两组间差异无统计学意义（P＞0.05）.术后角膜水肿情况：术后第1天,A组17.42％（23/132）,B组9.8％（16/163）,两组间比较差异有统计学意义（P＜0.05）.术后第7天,A组2.27％（3/132）,B组2.45％（4/163）,两组间比较差异无统计学意义（P＞0.05）.结论甲基纤维素联合透明质酸钠制作软壳技术比单用透明质酸钠更安全.