简介：HepatitisBvirus（HBV）isasignificantglobalpathogenandefficientcureforHBVpatientsisstillachallenginggoal.Wepreviouslyreportedthatacidicmucopolysaccharidefromstichopusjaponicusselenka（SJAMP）couldinhibitHBsAgandHBeAgexpressioninvitro.However,thepotentialanti-HBVeffectsofSJAMPinvivohavenotyetbeenexplored.Inthisstudy,weshowthatSJAMPexhibitspotentanti-HBVactivityinHBVtransgenicmiceinadose-dependentmanner.Specifically,sixtyHBVtransgenicmaleBALB/cmicewererandomlyselectedtoreceivethetreatmentofPBS,lowdoseSJAMP(30mgkg-1),middledoseSJAMP(40mgkg-1),highdoseSJAMP(50mgkg-1)andIFN(45IUkg-1)for30d.SJAMPtreatmentsuppressedserumHBV-DNA,andliverHBsAgandHBcAglevelsinHBV-transgenicmice.ThepresentstudyhighlightsthepotentialapplicationofSJAMPinHBVtherapy.

简介：TheTanlu(Tancheng-Lujiang)faultisoneofthemajorstructuresineasternChina,whichcutsacrossdifferentblocksandcontrolsthetectonicactivity.UsingtheseismicdatafromtheChinaEarthquakeNetworksCenter,weinvestigatethespatialvariationsoftheb-valueintheDabie-Sulu(Jiangsu-Shandong)organicbeltbycalculatingtheb-valueofeachgrid(1°×1°)from1970to2010.Thestudyshowsthat:theb-valueissmallerintheTanlufaultanditsadjacentarea,whichmightsuggestthatthemajorearthquakerecurrenceperiodisrelativelylongduetothelowerfrequencyofsmallearthquakeactivity.InbothsidesofTanlufault,theb-valueishigherattheedgeofSulublockandtheeasternpartofDabieorogenicbelt.ThebvaluesarehigherinNorthChinacentralorogenicbelt,andsmallearthquakeactivitywhichoccurredalongthecentralorogenicbeltisfrequent.Additionally,combinedwithgeologicalandgeophysicalstudy,wefindthattheb-valuehasacertaincorrespondencerelationshipwiththelithologicdistribution,whichinformsusthatseismicactivityfeaturesarecloselyrelatedtotheinhomogeneousmediainthecrust.

简介：Inthispaper,basedonGansuDigitalSeismicNetworkdatasince1990,wecalculatedb-valueand⊿b-valueoftheneighborhoodareabeforethe2013Minxian-ZhangxianM_S6.6,earthquake.Theresultsshowthattheearthquakeoccurredatthemarginofthesignificantlylowerb-valueareainsoutheastofGansuandbeforetheearthquaketheneighborhoodareahadanobviouslyabnormal⊿b-value.Fromtheearthquakeandthespatialdistributionoflowb-value,theregionstillhasthepossibilityofgeneratingdangerousstrongearthquakes.

简介：菹草（Potamogetoncrispus）衰亡的原因一直是水体生态修复的研究热点。已有的研究认为,强光照是促进菹草衰亡的关键因素。分别将菹草幼苗置于150μW/cm2剂量的中波紫外线（UV-B,波长为275-320nm）辐射下,设置4种UV-B辐射持续时间处理,其每日的持续辐射时间分别设定为0h（对照处理）、2h、4h和6h,对照处理下的菹草幼苗不接受UV-B辐射,仅接受长波紫外线（UV-A）辐射和光合有效辐射,监测各处理下菹草幼苗的生长、形态状况、石芽形成和萌发等指标。研究结果表明,每日6h的UV-B辐射,能促进菹草分枝,且能促进菹草衰亡;2h和4h的UV-B辐射,对菹草的影响较小,随着UV-B辐射时间的延长,菹草植株的株高、节间距和单株鲜质量明显下降,每日2h的UV-B辐射,能促进植株叶面积的增加;每日延长UV-B辐射时间,可以促进石芽的形成,但形成的石芽随着变态率的增加,其长度增加、宽度减小,石芽质量减轻,下一个生长季的萌发率降低,萌发出二苗的比率降低,萌发苗的各项生长指标随着辐射剂量增加而逐渐降低。因此,在春末、夏初,随着太阳辐射时间的增加,阳光中累计的UV-B辐射剂量增加,这可能是促进菹草大批衰亡的重要原因。

简介：Huanghe河三角洲是世界的大河之一，自从最后，Huanghe河里的Huanghe河三角洲paleoenvironmental进化是一个热问题冰川。基于联合AMS14核心DYZK1沉积标明日期在的C在亚底部侧面上Huanghe河三角洲和声学的顺序沉没了，phytolith分析在96件沉积样品上被执行。谷物尺寸参数，磁性的危险性与biostratum的垂直变化被相结合重建在Huanghe河三角洲的paleo沉积、气候的条件。在索引参数有一条重要垂直变化法律的学习结果表演，和Huanghe河三角洲的那沉积环境经历了河的facies-sealand转变的进化进程外形潮汐的完全外形浅海的faciesdelta外形自从26.0kaB。P...phytolith分析结果如下。第一，phytoliths被划分成矛尖状，光滑伸长，多刺伸长，一种特殊格律，长矩形，bulliform和其它类型。在不同sedimental环境，phytolith内容定期变化，显示phytolith在沉积环境有的一样装配稳定性的某个度。第二，矛尖状，phytoliths的光滑伸长和多刺伸长范畴在潮汐的扁平的外形和三角洲免职有更大的内容，当时一在浅海的外形的更小的内容和河的外形环境。通过变化系数的比较分析，第三，在沉积的主要phytolith范畴的内容在sealand转变外形和河的外形免职有一个更大的变化振幅，当在tidalflat外形和三角洲外形免职是更稳定的时。