简介：Oysterextractisaneffectivebioactivitycomponent.Ithasabundantnutritionalvalueandantiviral,antitumorandimmunedefensefunctions.Theroleofoysterextractintreatingliverinjuryhasbeenpaidmoreattention.WeuseWistarratstomakealcoholicliverdiseasemodelthroughinjectingalcoholintorats'stomachs.Theseratswererandomlydividedintofivegroups:modelgroup,controlgroup,low-dose,middle-doseandhigh-doseexperimentalgroupwithadoseof0.12gkg-1,0.40gkg-1,and1.20gkg-1alcoholic.Afternineweeks,serumbiomarkers(ALT,AST,TGandTCHO),malondialdehyde(MDA),glutathione(GSH),C3a,C5a,IL-17,TNF-ɑ,anti-MAA-HASIgG,CD3+,CD4+,CD8+,NKcellactivationandzinccontentwereassessed.Theresultsshowedthattheserumbiomarkers(ALT,AST,TGandTCHO),MDAcontent,anti-MAA-HSAIgG,serumC3a,C5aIL-17andTNF-ɑlevelsofoysterextracttreatmentgroupsweresignificantlydecreasedincomparisonwithmodelgroup.Onthecontrary,GSHshowedadversetrend.SerumCD3+,CD4+andNKcellactivationweresignificantlyincreasedinmiddle-dosegroupandhigh-dosegroupcomparedwithmodelgroup,andtherewasdecreaseofCD8+activityinhigh-dosegroup.PlasmaZnlevelwasdecreasedinmodelgroupcomparedwiththatincontrolgroup.Meanwhile,MeanplasmaZnlevelsincreaseddramaticallyfollowingthedoseincreaseofagivenoysterextract.