简介：GliomacelllineC6culturedonsiliconsurfacesmodifiedbydifferentchemicalfunctionalgroups,includingmercapto（-SH）,carboxyl（-COOH）,amino（-NH2）,hydroxyl（-OH）andmethyl（-CH3）groups,wasstudiedheretoinvestigatetheinfluenceofsurfacechemistryonthecellproliferation,adhesionandapoptosis.AFMconfirmedthesimilarcharacteristicofdifferentfunctionalgroupsoccupation.TheadheringC6exhibitedmorphologicalchangesinresponsetodifferentchemicalfunctionalgroups.TheC6adheredto-COOH,-NH2,-OHand-CH3surfacesandflattenedmorphology,whilethoseon-SHsurfaceexhibitedthesmallestcontactareawithmostlyroundedmorphology,whichledtothedeathofcancercells.TheresultsofMTTassayshowedthatthe-COOHand-NH2groupspromotedceilproliferation,whilethe-SHsignificantlyinhibitedtheproliferation.Comparedwithotherchemicalfunctionalgroups,the-SHgroupexhibiteditsuniqueeffectonthefateofcancercells,whichmightprovidemeansforthedesignofbiomaterialstopreventandtreatglioma.