简介:Diabetesmellitus(DM)isachronicsystemicdiseasecharacterizedbyhyperglycemia,withvariouspatho-genicmechanisms.Fromabsoluteorrelativeinsulindeficiency,patientswithDMoftendemonstratevari-ouslevelsofmetabolicdisorders.MajorclinicalmanifestationsofDMincludemetabolicdisorders,vascu-larlesions,circulatorydisturbancesandneurologiccomplications.AlongwithadvancesinDMresearch,re-portsofDMrelatedtinnitusandhearingimpairmenthaveincreasedcontinuously.ResearchonDMrelatedauditorysystemdysfunctionhasfocusedoncochlearmicrocirculation,cellularhomeostasis,geneticsandag-ing.Cochlearmicrocirculationplaysanimportantroleincochlearphysiologyanditsdisordersareassociat-edwithmanyinnereardiseases.Ischemiaandsubsequentreperfusionseenincochlearmicrocirculationdis-ordersareimportantfactorsinhearingdamage.UnderstandingcochlearmicrocirculationandstructuralaswellasfunctionalchangesinDMpatientswithhearinglossandtheircausalfactorswillhelprevealpatho-genicmechanismsindiabetichearinglossandprovidenewideasindevelopinginterventionsandpreventingdamagescausedbydiabetes.
简介:Atotalof30studentsscoringbetween12and20ontheTestAnxietyScalewhohadbeenexhibitingananxiousstate>24hours,and30normalcontrolstudentswererecruited.IndicesofheartratevariabilitywererecordedusinganActiheartelectrocardiogramrecorderat10minutesbeforeauricularpressing,inthefirsthalfofstimulationandinthesecondhalfofstimulation.Theresultsrevealedthatthestandarddeviationofallnormaltonormalintervalsandtherootmeansquareofstandarddeviationofnormaltonormalintervalsweresignificantlyincreasedafterstimulation.Theheartratevariabilitytriangularindex,very-low-frequencypower,low-frequencypower,andtheratiooflow-frequencytohigh-frequencypowerwereincreasedtodifferentdegreesafterstimulation.Comparedwithnormalcontrols,therootmeansquareofstandarddeviationofnormaltonormalintervalswassignificantlyincreasedinanxiousstudentsfollowingauricularpressing.Theseresultsindicatedthatauricularpressingcanelevateheartratevariability,especiallytherootmeansquareofstandarddeviationofnormaltonormalintervalsinstudentswithpre-examanxiety.
简介:摘要目的探讨乙肝病毒前S1抗原(Pre-S1Ag)与HBV血清标志物(HBVM)同步检测的临床价值。方法对确诊的380例乙肝病例空腹抽血,采用ELISA法及HAMILTN全自动酶联免疫分析仪同步检测Pre-S1Ag与HBVM(HBsAg、抗-HBs、HBeAg、抗-HBe、抗-HBc),并对结果进行比较分析。统计学处理采用χ2检验。结果统计显示PreS1Ag的检出率HBsAg、HBeAg、HBcAb阳性组(78.8%)明显高于HBsAg、HBeAb、HBcAb阳性组(41.6%),差异有显著性(χ2=21.04,P<0.01);HBsAg、HBeAg阳性组PreS1Ag阳性率(79.3%)明显高于HBsAg、HBcAb阳性组(25.3%),提示HBeAg阳性组中PreS1Ag阳性率明显高于HBeAg阴组,差异有显著性(χ2=21.49,P<0.01);提示PreS1Ag是一个与HBeAg同时存在的较好指标。结论前S1抗原与病毒复制有关,与HBeAg具有一致性;与HBVM同步检测,可减少和避免HBeAg系统发生变异所致的假阴性对临床的误导。
简介:AIM:Tomeasurecentralcornealthickness(CCT)andpre-cornealtearfilmthicknessusingtheGalileidualScheimpfluganalyzer(GSA)inNewZealandWhiterabbits.METHODS:TennormalNewZealandWhiterabbits(20eyes)wereincludedinthisstudy.Withtheassistanceof0.1%fluorescein,thepre-cornealtearfilmcanbewellvisualized.BotheyesofeachrabbitwerescannedoncewiththeGSApre-andpost-instillationof1μL0.1%fluorescein.ThedifferencebetweenthetwomeasurementsofCCT(4-mmdiameter)wasrecordedasthepachymetricvaluesofthecentraltearfilm.RESULTS:TheCCTofpre-andpost-instillationwas388.8±9.5μmand407.0±10.5μm,respectively.Afterapairedt-testanalysis,thecentralpre-cornealtearfilmthicknessof4mmdiameterwas18.2±5.31μmwitha95%confidenceintervalof(15.7,20.6)μm(P<0.001).CONCLUSION:GSAcanbeusedtomeasureCCTandanalyzecentraltearfilmthicknessofrabbitswiththehelpoffluorescein.