简介：Developinganewjournalisnotaneasytask.Icanthinkoffourgoodreasons,andthereareprobablymore.Thesereasonsareasfollows:1.Potentialauthorsmaybereluctanttosendmanuscriptstoanunknown"newjournal."2.Potentialauthorsmaybeconcernedaboutthelackofan"impactfactor."3.Potentialauthorsmayhaveconcernsaboutreadershipoftheauthors'work.4.Potentialreviewersmaybereluctanttoreviewmanuscriptssenttoanewjournalbecausemosthavemultiplemanuscriptstoreviewsenttothemfromknownjournals.

简介：严重流行性感冒为人在它的毒力仍然保持不平常。复杂并发症或最终，从这些感染产生的死亡经常与proinflammatorycytokine生产的hyperinduction被联系，它也作为‘被知道；cytokinestorm’；。为这疾病，immunomodulatory治疗可以改进结果，这被建议了，与或没有抗病毒的代理人的联合。这里，我们考察免疫系统的各种各样的受动器怎么开始cytokine暴风雨并且在主人加重病理学的损坏的当前的文学。我们也在严重流行性感冒为cytokine暴风雨的治疗考察一些当前的immunomodulatory策略，包括corticosteroids，peroxisome激活proliferator的受体收缩筋，sphingosine-1-phosphate受体1收缩筋，cyclooxygenase-2禁止者，抗氧化剂，anti-tumour-necrosis因素治疗，静脉内的免疫球蛋白治疗，statins，arbidol，植物，并且另外的潜在的治疗学的策略。

简介：Flaviviruses包括约70个密切相关的RNA病毒。这些包括几忍受蚊子的病原体，例如黄发烧病毒(YFV)，登革热病毒(DENV)，和日本脑炎病毒(JEV)，它能引起重要人的疾病并且因此具有大医药重要性。对YFV和JEV的疫苗为decades;在人成功地被使用了；然而，一支DENV疫苗的发展遇到了可观的障碍。这里，我们考察疫苗对YFV得到提供一些卓见进一支保护的DENV疫苗的发展的保护的有免疫力的回答。

简介：PolysaccharidesfromnumeroustraditionalChinesemedicineshavebeenprovenasthebioactiveingredientsandarehenceusedasthequalitycontrolmarkers.However,theassessmentcriteriaalwaysshowapoorspecificity,duetothelackofmaticcomparisonamongtheanalogousherbs.Inthepresentstudy,twosimilarmaterials,namelysea-tangleandsargassum,wereselectedasthemodelherbstodevelopmorespecificmethodsforqualitycontrol.Twowell-establishedmethods,determinationofthetotalpolysaccharidescontentandmonosaccharidescompositionanalysis,werebothemployed.Baseduponthequantitativeresults,theevaluationcriteriaofthepolysaccharidescontentsofnotlessthan2.0%and1.7%wereproposedforsea-tangleandsargassum,tively.NineidenticalmonosaccharidederivativesappearedontheHPLCchromatogramsofthehydrolysisandderivatizedsolutionsofthetwodrugs.Principalcomponentanalysisandorthogonalpartialleastsquaresdiscriminantanalysisusingthepeakareasofmonosaccharidesderivativesasthevariableswereperformed,andtheresultsindicatedthatmannuronicacidandxylosewiththeoppositeconcentrationsinthetwodrugswerethedifferentialcomponents.Adiscriminativecriterionusingthepeakarearatioofthesetwomonosaccharidesderivativeswasproposedforthequalitativeidentification.Inconclusion,amorespecificandquantitativequalitycontrolmethodwasdevelopedforsea-tangleandsargassum.