简介：BACKGROUND:Strokepresentsasatransientorchronicbraindysfunctionandisassociatedwithhighmorbidityandhighmortality.Thedoctorsandscientistswouldliketoarguehowtoenhancethevalidityoftherehabilitationtreatmentandhowtofurtherimprovetheleveloftreatmentonstroke.OBJECTIVE:TheaimofthisstudywastoquantitativelyanalyzethecurrentworldwideprogressinresearchonstrokerehabilitationtreatmentbasedonWebofSciencedatabaseandClinicalTrial.govinthepast10years.METHODS:WeconductedaquantitativeanalysisofclinicaltrialarticlesregardingstrokerehabilitationpublishedinEnglishfrom2003to2013andindexedintheNationalInstitutesofHealthClinicalTrialsregistryandWebofSciencedatabases.DataweredownloadedonMarch15,2013.RESULTS:(1)From2003to2013,2654clinicaltrialsinvestigatingstrokewereindexedinClinicalTrials.gov.Therewereonly58clinicaltrialsregisteredin2003,andtherewasamarkedincreasefrom2005.Atotalof605clinicaltrialsontherehabilitationofstrokewereconductedinthepast10years.(2)TheanalysisshowedthatmostofthetrialsinthefieldwereregisteredbyNorthAmericaninstitutions.WithrespecttotheAsiancountries,ChinaandTaiwanareaofChinaalsopublishedareasonableproportionofthetrials,butcomparativelyspeaking,thenumberoftrialsisreallyrare.Mostoftheinterventionsweredrugs,followedbythedevices,andbehavioralinterventionswererankedthird.(3)Inthepast10years,therewere4052studiesonstrokeindexedbyWebofSciencedatabase.CONCLUSION:Fromperspectiveofresearchprogress,wefoundthatthenumberofclinicaltrialsandpapersonstrokerehabilitationhasincreasedsignificantlyinthepast10years,betweenthemaremarkablepositivecorrelationexists.

简介：Thelasttenyearshaveseenremarkableprogressincancerresearch.However,despitesignificantbreakthroughsintheunderstanding,prevention,andtreatmentofcancer,thediseasecontinuestoaffectmillionsofpeopleworldwide.Cancer’scomplexitycompoundedwithfinancial,policyandregulatoryroadblockshasslowedtherateofprogressbeingmadeagainstcancer.Inthispaper,wereviewafewofthemostrecentbreakthroughsthatarefuelingmedicaladvancesandbringingnewhopeforpatientsaffectedbythisdevastatingdisease.Wealsoaddressthechallengesfacingusandtheopportunitiestoacceleratefutureprogressagainstcancer.TheeffortsoftheAmericanAssociationforCancerResearch(AACR)toaddressthecancerburdenalreadyextendbeyondthebordersoftheUnitedStatesofAmerica.TheAACRiscommittedtoincreasingitseffortstostemthetideofcancerworldwidebypromotinginnovativeprograms,strategies,andinitiativesforcancerresearchersandallthoseengagedincancer-relatedbiomedicalsciencesaroundtheworld.

简介：Irradiationfromdiversesourcesisubiquitousandcloselyassociatedwithhumanactivities.Radiationtherapy(RT),animportantcomponentofmultipleradiationorigins,isacommontherapeuticmodalityforcancer.Moreimportantly,RTprovidessignificantcontributiontooncotherapybykillingtumorcells.However,duringthecourseoftherapy,irradiationofnormaltissuescanresultinawiderangeofsideeffects,includingself-limitedacutetoxicities,mildchronicsymptoms,orsevereorgandysfunction.Althoughnumerouspromisingradioprotectiveagentshaveemerged,onlyafewhavesuccessfullyenteredthemarketbecauseofvariouslimitations.Atpresent,thewidelyacceptedhypothesisforprotectionagainstradiation-causedinjuryinvolvestheWntcanonicalpathway.ActivatingtheWnt/β-cateninsignalingpathwaymayprotectthesalivarygland,oralmucosa,andgastrointestinalepitheliumfromradiationdamage.Theunderlyingmechanismsincludeinhibitingapoptosisandpreservingnormaltissuefunctions.However,aberrantWntsignalingunderliesawiderangeofpathologiesinhumans,anditsvariouscomponentscontributetocancer.Moreover,studieshavesuggestedthatWnt/β-cateninsignalingmayleadtoradioresistanceofcancerstemcell.ThesefactsmarkedlycomplicateanydefinitionoftheexactfunctionoftheWntpathway.