简介：Tumormetastasisisthedominantcauseofdeathincancerpatients.However,themolecularandcellularmechanismsunderlyingtumormetastasisarestillelusive.Theidentificationofproteinmoleculeswiththeirexpressionscorrelatedtothemetastaticprocesswouldhelptounderstandthemetastaticmechanismsandthusfacilitatethedevelopmentofstrategiesforthetherapeuticinterventionsandclinicalmanagementofcancer.Proteomicsisasystematicresearchapproachaimingtoprovidetheglobalcharacterizationofproteinexpressionandfunctionundergivenconditions.Proteomictechnologyhasbeenwidelyusedinbiomarkerdiscoveryandpathogeneticstudiesincludingtumormetastasis.Thisarticleprovidesabriefreviewoftheapplicationofproteomicsinidentifyingmolecularfactorsintumormetastasisprocess.Thecombinationofproteomicswithotherexperimentalapproachesinbiochemistry,cellbiology,moleculargeneticsandchemistry,togetherwiththedevelopmentofnewtechnologiesandimprovementsinexistingmethodologieswillcontinuetoextenditsapplicationinstudyingcancermetastasis.

简介：Wereportthefabricationprocessofpiezoelectriccellulosepaperandtheenhancementmethodofitspiezoelectricproperty.Stretchingmethodwithdifferentwet-drawingratioswasintroducedtoincreasethepiezoelectricpropertyofcellulosepaperduringregenerationprocess.ItisobservedthattheYoung’smodulusandthepiezoelectricchargeconstantsareverydependentonthedrawingratioandthedirectionofnanofibrilsofpiezoelectricpaper.Usingtheenhancedpiezoelectricproperty,weprovethattheflexibleregeneratedpiezoelectriccellulosecanbeappliedtothepotentialacousticapplicationssuchasthinpiezoelectricpaperspeaker.

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简介：ThepropertiesofFeMnSiCrNishapememoryalloywereinvestigated.TheresultsshowthatthebestshapememoryeffectofFel4Mn6Si9Cr5Nialloyis85%.Thetransformationamountoftheε→γtransformationisnotcompleteafterheatingthealloyto1000K,AsandAfpointsdropwithincreasedtransformationenthalpy(△Hγ→ε)bythermalcyclingandincreasedprestrain.Thealloyshowsalsogoodcreepandstressrelaxationresistance.Inaddition,thealloyhavingatensileforceof20kNandasealingpressureof6MPacansatisfyrequirementsforpossibleindustrialapplicationonpipejoints.

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简介：Thispaperdescribesanovelwavelet-basedapproachtothedetectionofabruptfaultofRotorcraftUnmannedAerialVe-hicle(RUAV)sensorsystem.Byuseofwavelettransformsthataccuratelylocalizethecharacteristicsofasignalbothinthetimeandfrequencydomains,theoccurringinstantsofabnormalstatusofasensorintheoutputsignalcanbeidentifiedbythemulti-scalerepresentationofthesignal.Oncetheinstantsaredetected,thedistributiondifferencesofthesignalenergyonalldecomposedwaveletscalesofthesignalbeforeandaftertheinstantsareusedtoclaimandclassifythesensorfaults.

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简介：ChengandChurchalgorithmisanimportantapproachinbiclusteringalgorithms.Inthispaper,theprocessoftheextendedspaceinthesecondstageofChengandChurchalgorithmisimprovedandtheselectionsoftwoimportantparametersarediscussed.Theresultsoftheimprovedalgorithmusedinthegeneexpressionspectrumanalysisshowthat,comparedwithChengandChurchalgorithm,thequalityofclusteringresultsisenhancedobviously,theminingexpressionmodelsarebetter,andthedatapossessastrongconsistencywithfluctuationontheconditionwhilethecomputationaltimedoesnotincreasesignificantly.

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简介：DNAsequencescanbetreatedasfinite-lengthsymbolstringsoverafour-letteralphabet(A,C,T,G).Asauniversalandcomputablecomplexitymeasure,LZcomplexityisvalidtodescribethecomplexityofDNAsequences.Inthisstudy,aconceptofconditionalLZcomplexitybetweentwosequencesisproposedaccordingtotheprincipleofLZcomplexitymeasure.AnLZcomplexitydistancemetricbetweentwononnullsequencesisdefinedbyutilizingconditionalLZcomplexity.BasedonLZcomplexitydistance,aphylogenetictreeof26speciesofplacentalmammals(Eutheria)withthreeoutgroupspecieswasreconstructedfromtheircompletemitochondrialgenomes.Onthedebatethatwhichtwoofthethreemaingroupsofplacentalmammals,namelyPrimates,Ferungulates,andRodents,aremorecloselyrelated,thephylogenetictreereconstructedbasedonLZcomplexitydistancesupportsthesuggestionthatPrimatesandFerungulatesaremorecloselyrelated.

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简介：Abiomimetichipjointsimulatorthatcanbeusedtoevaluatetheoutcomeofthecementedtotalhipreplacementhasbeendesigned,manufacturedandevaluated.Thesimulatorproducesmotionintheextension/flexionplane,withasockettorotateinternal/externally.Atthesametimeadynamicloadingcycleisapplied.Avalidationtestwasperformedonacementedfemoralstemwithinanovelcompositefemur.Thebonequalityhasastrongeffectonthestemmigrationandontheintegrityoftheinterfaces.Themigrationofthestemisacombinationof3-Dtranslationandrotationofthestem.Underthesameloadingconditions,weakboneallowsmorestemmigrationthanstrongbone.Thereisagreatdecreaseinthestrengthofthestem-cementinterfaceafterthedynamictest,andtheweakbonecompositeexhibitedagreaterreductionininterfacialstrengththanthestrongbonecomposite.Thedecreaseoftheinterfacialstrengthindicatesthattheprimarybondingbetweenthestemandthecementmantlehaddeterioratedandtheintegrityofstem-cementinterfacewasdamaged.Thestudydemonstratesthevalueofusingahipjointsimulatortoinvestigatestemmigrationandinterfaceintegritywithinthecementedhipreplacement,suggestingthatmethodcanbeusedforinvitroevaluationofthebiomaterialsusedinthecementedhipreplacements.

简介：单个核苷酸多型性(SNP)是决定任何二个无关的个人之间的差别的基因变化。各种各样的人口组能用SNP与对方被区分开来。例如，HapMap数据集与大约1000万SNP有四个人口组。为人的进化，种族变化，和人口赋值上的更多的卓见，我们建议发现哪个SNP在决定人口组是重要的然后作为输入特征用这些相关SNP分类不同人口。在这研究，我们开发了评价措施的修改t测试并且把它用于HapMap遗传型数据。第一，我们为赋值包括F统计和增进知识的海角与另外的特征重要性措施比较评价所有SNP。第二，我们作为输入选择最高度评价的SNP的不同数字到一个分类器，例如支持向量机器，以便发现最好的特征相应于最好的分类精确性的子集。试验性的结果证明建议方法在发现在决定人口组是重要的SNP是很有效的，与减少的计算负担和更好的分类精确性。

简介：Thethree-dimensional(3D)structurepredictionofproteinsisanimportanttaskinbioinformatics.Findingenergyfunctionsthatcanbetterrepresentresidue-residueandresidue-solventinteractionsisacrucialwaytoimprovethepredictionaccuracy.Thewidelyusedcontactenergyfunctionsmostlyonlyconsiderthecontactfrequencybetweendifferenttypesofresidues;however,wefindthatthecontactfrequencyalsorelatestotheresiduehydrophobicenvironment.Accordingly,wepresentanimprovedcontactenergyfunctiontointegratethetwofactors,whichcanreflecttheinfluenceofhydrophobicinteractiononthestabilizationofprotein3Dstructuremoreeffectively.Furthermore,afoldrecognition(threading)approachbasedonthisenergyfunctionisdeveloped.Thetestingresultsobtainedwith20randomlyselectedproteinsdemonstratethat,comparedwithcommoncontactenergyfunctions,theproposedenergyfunctioncanimprovetheaccuracyofthefoldtemplatepredictionfrom20%to50%,andcanalsoimprovetheaccuracyofthesequence-templatealignmentfrom35%to65%.

简介：蚜虫属glycinesMatsumura是在亚洲和北美洲的大豆的一个重要害虫。Hymenopteraparasitoids玩在大豆蚜虫的控制的一个关键角色。parasitoids的正确鉴定是先于对他们的潜在的生物控制代理人的评价的关键步。攻击大豆蚜虫的种类的多数的精确鉴定经常要求精致的标本准备和专家分类知识。在这研究，我们由使用跟随初步的词法鉴定的一条DNAbarcoding途径便于大豆蚜虫parasitoids的鉴定。我们从mitochondrialCOI基因和28SrDNA的D2区域产生了DNA顺序数据在种类在中国从大豆蚜虫出现以内并且在parasitoid之间估计基因变化。属于五个家庭的10个类的十五Hymenopteraparasitoid种与很少intra特定的变化(为28S的0.09%±0.06%和为COI的0.36%±0.18%)和大种间的分叉(为28S的30.46%±3.42%和为COI的20.4%±1.20%)被识别。

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简介：Methoprene(少年荷尔蒙的类似物)申请并且在蛋白质节食喂被知道提高男甜瓜苍蝇，BactroceracucurbitaeCoquillett(双翅目：Tephritidae)，交配成功。在这研究，我们在男B上调查了这些处理的效果。cucurbitae禁止女性的能力重新配偶。当14-d-old女性在蛋白质节食被喂时，6-d-old男性暴露于下列处理之一：(i)methoprene的热门申请并且在蛋白质节食喂了；(ii)没有methoprene但是在蛋白质节食喂了；(iii)methoprene并且喂糖仅仅；并且(iv)喂糖，14-d-old男性充当了控制。处理没在男性压抑女性的能力上有效果重新配偶与控制相比的感受性。交配，剥夺蛋白质的男性更高出现了的女性重新配偶比女性，第一与喂蛋白质的男性一起交配了的感受性。Methoprene和蛋白质食谱相互作用在交配成功在期间的男性上有积极效果第一并且女性的secondmating。显著地，首先与喂糖的男性一起交配的更多的女性与首先交配，methoprene对待的喂蛋白质的男性和喂蛋白质的男性一起重新交配对更可能与同样对待的男性一起重新交配。女性交配潜伏(开始交配的时间)与喂蛋白质的男性一起是显著地更短的，并且交配持续时间与剥夺蛋白质的男性相比与喂蛋白质的男性一起是显著地更长的。这些结果在集成无菌的昆虫技术的甜瓜苍蝇的区域宽的控制作为不育的男性的预映处理在methoprene或饮食的蛋白质的上下文被讨论(坐)。