简介:摘要 目的 对3例HIV/AIDS患者因接种新冠疫苗引起的严重副反应案例进行调查,分析造成严重副反应的原因,研究HIV/AIDS患者接种新冠疫苗的最佳时机。方法 对3例HIV/AIDS接种新冠疫苗副反应案例从抗病毒治疗、机会性感染控制、CD4淋巴细胞变化、病毒载量抑制及副反应控制情况进行回顾性研究。结论 免疫缺陷人群接种新冠疫苗要选择恰当时机,接种新冠疫苗会对免疫缺陷人群的免疫功能造成短期的抑制。讨论 HIV/AIDS患者应在艾滋病毒得到有效抑制、免疫功能良好,没有严重机会性感染的情况下接种新冠疫苗,从而避免副反应的发生。
简介:Despitethehnpactofhighly-activemltiretroviraltherapy(HAART),manifestedasmarkedreductionsintheincidenceofopwrtunistieinfectionsinthelast5,years,respiratoryproblemsstillconstituteamajorburdenofdiseaseinthoseinfectedwithHIV.ReasonsforthisincludethelimitedavailabilityofHAART.worldwide,thefailureofsustainedviralsuppressioninupto50%ofpatientstakingHAART,failureofprophylaxisforspecificopportunisticinfectiorrs,andanincreasingnumberofpatientspresentingwithpreviouslymldiagnosedadvancedHIVinfection.
简介:摘要目的探讨抗逆转录病毒治疗(anti-retroviral therapy,ART)不同时长对HIV/AIDS患者代谢的影响。方法单中心横断面研究,选择2020年6月在首都医科大学附属北京地坛医院门诊随诊的424例HIV/AIDS患者,根据不同治疗时长分成四组:Ⅰ组(0.5~2年)、Ⅱ组(2~4年含2年)、Ⅲ组(4~6年含4年)、Ⅳ组(≥6年),比较各组血脂、肾功、血糖、肝功异常的差异性。结果高胆固醇血症发生率:Ⅰ组9/106(8.5%)、Ⅱ组17/134(12.7%)、Ⅲ组22/123(17.9%)、Ⅳ组4/61(6.6%),p=0.076;高甘油三酯血症发生率:Ⅰ组32/106(30.2%)、Ⅱ组58/134(43.3%)、Ⅲ组50/123(40.7%)、Ⅳ组27/61(44.3%),p=0.152;高低密度脂蛋白胆固醇血症发生率:Ⅰ组8/106(7.5%)、Ⅱ组17/134(12.7%)、Ⅲ组15/123(12.2%)、Ⅳ组3/61(4.9%),p=0.249;低高密度脂蛋白胆固醇血症发生率:Ⅰ组48/106(45.3%)、Ⅱ组66/134(49.3%)、Ⅲ组55/123(44.7%)、Ⅳ组33/61(54.1%),p=0.612;估算肾小球滤过率(eGFR)<90 ml/min/1.73 m2发生率:Ⅰ组4/106(3.8%)、Ⅱ组6/134(4.5%)、Ⅲ组6/123(4.9%)、Ⅳ组2/61(3.3%),P=0.953;eGFR与治疗时长呈负相关(r=-0.165,p<0.001);低磷血症发生率:Ⅰ组7/106(6.6%)、Ⅱ组7/134(5.2%)、Ⅲ组12/123(9.8%)、Ⅳ组6/61(9.8%),P=0.478;高尿酸血症发生率:Ⅰ组26/106(24.5%)、Ⅱ组35/134(26.1%)、Ⅲ组28/123(22.8%)、Ⅳ组10/61(16.4%),P=0.508;糖尿病发生率:Ⅰ组1/106(0.9%)、Ⅱ组9/134(6.7%)、Ⅲ组6/123(4.9%)、Ⅳ组3/61(4.9%),P=0.140;γ-谷氨酰基转移酶>60U/L发生率:Ⅰ组23/106(21.7%)、Ⅱ组34/134(25.4%)、Ⅲ组25/123(20.3%)、Ⅳ组12/61(19.7%),P=0.736;丙氨酸氨基转移酶>50 U/L发生率:Ⅰ组23/106(21.7%)、Ⅱ组33/134(24.6%)、Ⅲ组24/123(19.5%)、Ⅳ组12/61(19.7%),p=0.761。结论治疗半年以上HIV/AIDS患者血脂紊乱类型以低HDL、高TG血症为主,血脂异常发生率不随治疗时间延长而升高。eGFR随治疗时间延长呈下降趋势并且需关注低磷血症及高尿酸血症的发生。ART药物对肝功的损伤持续存在。
简介: 获得性免疫功能缺陷综合征(acquiredimmuneodeficiencysyndrome,AIDS)亦称艾滋病,这个幽灵自闯入全世界人类的生活以来,通过性行为(尤其是同性恋者)、输血及使用血液制品、静脉注射毒品和母婴传播等途径的播散而泛滥于全球,人类与AIDS的斗争愈演愈烈. ……
简介:AIDSassociatedmalignancies(ARL)isamajorcomplicationassociatedwithAIDSpatientsuponimmunosuppression.Chronicallyimmunocompromisedpatientshaveamarkedlyincreasedriskofdevelopinglymphoproliferativedisease.Intheeraofpotentantiretroviralstherapy(ARV),themalignantcomplicationsduetoHIV-1infectionhavedecreasedindevelopednationswhereARVisadministered,butstillposesamajorproblemindevelopingcountrieswhereHIV-1incidenceishighandARVisstillnotyetwidelyavailable.EveninARVtreatedindividualsthereisaconcernthattheprolongedsurvivalofmanyHIV-1carriersislikelytoeventuallyresultinanincreasednumberofmalignanciesdiagnosed.MalignanciesthatwerefoundtohavehighincidenceinHIV-infectedindividualsareKaposi'ssarcoma(KS),Hodgkin'sdisease(HD)andnon-Hodgkin'slymphoma(NHL).TheincidenceofNHLhasincreasednearly200foldinHIV-positivepatients,andaccountsforagreaterpercentageofAIDSdefiningillnessintheUSandEuropesincetheadventofHAARTtherapy.TheseAIDSrelatedlymphomasaredistinctfromtheircounterpartsseeninHIV-1seronegativepatients.ForexamplenearlyhalfofallcasesofARLareassociatedwiththepresenceofagammaherpesvirus,EpsteinBarrvirus(EBV)orhumanherpesvirus-8(HHV-8)/Kaposi'ssarcomaassociatedherpesvirus(KSHV).ThepathogenesisofARLsiscomplex.B-cellproliferationdrivenbychronicantigenemiaresultingintheinductionofpolyclonalandultimatelymonoclonallymphoproliferationmayoccurinthesettingofsevereimmunosuppression.
简介:Objective:ToincorporatestudentsandotherlocalcommunitypartnersincreatingacollaborativeNanjingWorldAIDSDayexhibition.Background:StigmaanddiscriminationcontinuetocomplicateeffectiveWorldAIDSDayactivitiesinChina.IncludingforeignstudentsinWorldAIDSDaycampaignsbroadensthepotentialChineseaudienceaswellasmakingthegovernment'sAIDSpoliciesmoretransparent.Methods:Inordertobroadenthepotentialaudience,relevantmedia(television,radio,newspaper)werenotifiedofthe2003NanjingWorldAIDSDayExhibition.TheexhibitionrepresentedauniquecollaborationbetweenNanjingUniversityandtheChineseNationalCenterforSTDandLeprosyControl,dependingonforeignandChinesestudentsatseverallevels.Inaddition,closecontactsattheJiangsuProvincialHealthBureauhelpedtocoordinatelocalexpertsanddistributionofcondoms.Results:Thismulti-disciplinarycooperativeexhibitionwassuccessfullycompleted.Severalmajormediasourcescoveredtheevent.Conclusions:ThesuccessofthiscampaignsuggeststhatotherurbancitieswithsignificantforeignstudentpopulationscouldbenefitfromincludingforeignandChinesestudentsinfutureWorldAIDSDaycampaignactivities.
简介:DecemberfirstwasWorldAIDSDay.Lastyear,thecampaign(运动;活动)centeredonwomenandgirls.TheymadeupalmosthalfofallpeopleinfectedwiththevirusHIVthatcausesAIDS.AndH1Vwasspreadingfasteramongwomenthanmeninmostareasoftheworld.Thesefindings(发现)werefromtheyearlyreportbytheUnitedNationsandtheWorldHealthOrganization,aUNagency
简介:GreaterEfortstoCombatAIDSHIV-infectedpatientsandthosewithothersexualy-transmiteddiseases(STDs)haveincreaseddrasticalyinrece...
简介:DevelopingawidelyadaptableAIDSvaccineisthegoalofscientistswhofightagainstglobalproliferationofthedeadlydisease.NoW,somearefocusingtheirstudyonChina,believingthatthecountrymaybetheperfectpartnerforacollaborationinvaccineresearch.AninternationalAIDSvac...