简介：摘 要：本文根据徐州 苏 02井水位动态干扰因素及其影响的调研结果 ，以井区水文地质条件为基础，研究了各类干扰的影响，并根据干扰异常的成因归纳出典型的干扰异常因素。

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简介：摘要A recent epidemic of pneumonia cases in Wuhan China was caused by a novel coronavirus with strong infectivity, the 2019 novel coronavirus (2019-nCoV). The article provides the pulmonary rehabilitation (PR) methods in the principle of 4S (simple, safe, satisfy, save) for patients with pneumonia caused by the novel coronavirus, shows how to establish a ventilative and convectional PR environment to prevent the spread of virus through droplets, how to guide the patients to carry out PR, how to carry out respiratory muscle training, effective cough, expectoration, sneeze, general exercise, digestive function rehabilitation and psychological rehabilitation, and how to clean and disinfect the PR environment.

简介：内容摘要：板书的设计形式是多种多样的，独具匠心的板书设计，既能引起学生的有意注意，又能激发学生学习的兴趣；既能传授知识，又能活跃学生思维；既能陶冶学生情操，又能启迪学生智慧，在语文教学中发挥着不可估量的作用。

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简介：AbstractTrauma is the leading cause of death in people under the age of 45 years, and it has gained wide attention from academics worldwide. Therefore, more and more studies have reported on trauma and related fields in recent decades. In 2019, Chinese Journal of Traumatology (CJTEE) published 69 articles covering traffic medicine, wound healing, bone trauma, emergency care, and other hot topics of traumatology. Here we reviewed a series of articles published in CJTEE on the topics mentioned above, try to give a brief introduction of progress in trauma field.

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简介：摘要为掌握各专业医疗质量状况，从2015年开始，国家卫生健康委员会医政医管局质量处每年均组织撰写包括病理在内各专业的全国质量报告。根据2019年抽查的资料完整的3 643家医院病理科质控指标，统计分析如下：（1）全国平均每百张病床病理医师数量为0.55，约24.4%的病理科仅有1名病理医师，二级医院中，46.3%的病理科仅有1名病理医师。（2）全国平均每百张病床病理技术人员数为0.46；病理医师与技术人员的严重缺乏成为制约病理学发展的重要因素。（3）各医院术中快速病理诊断及时率、小活检标本诊断及时率及细胞学诊断及时率均在90%以上，同时发现由于工作量大、辅助检查项目多等因素，三级医院的诊断及时率低于二级医院。（4）免疫组织化学室间质控方面，三级公立医院、二级公立医院及民营医院病理科未参加室间质评的比例分别为35.8%、86.4%及78.2%。（5）开展分子病理检测的三级公立医院中，约76.2%的病理科未参加过室间质评。（6）细胞病理诊断质控符合率和术中快速诊断与石蜡诊断符合率均>96%；二级公立医院和民营医院术中快速诊断开展率和平均数量，远远低于三级公立医院。2019年，国家病理质控中心共举办了17个全国室间质评项目，参加的医院数量为2 431家次，专项培训人数12 286人次，发表分子检测指南1个。国家病理质控中心制定了省级病理质控中心工作量化考核方案，根据不完全统计，2019年全国32个省级病理质控中心共开展各种室间质评180项，覆盖医院4 373家次；督导检查下级医院754家，专项质控培训14 869人次。

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简介：AbstractObjective:Genital chlamydial infection is a globally common sexually transmitted infection caused by Chlamydia trachomatis. This study aimed to describe the epidemiological characteristics of the disease reported in China in 2019.Methods:Genital chlamydial infection cases were identified in 105 national sexually transmitted disease surveillance sites from the National Notifiable Infectious Disease Reporting System, which covers 31 provinces, autonomous regions, and municipalities in Chinese mainland. Data were collected and used to calculate the overall incidence, and the incidences per surveillance site, province, sex, and age group.Results:In 2019, there were 50,874 new cases of genital chlamydial infection reported in China, corresponding to an incidence of 55.32 cases per 100,000 population, and comprising a 9.98% increase from 2018 (50.30 cases per 100,000 population). The highest incidences of genital chlamydial infection occurred in Zhejiang, Guangdong province, Guangxi autonomous region, and Hainan province (average 137.49-233.37 cases per 100,000 population). The incidence of genital chlamydial infection was much higher in females than males, with a female-to-male ratio of 3.09 (84.55 per 100,000 population vs 27.35 per 100,000 population). The highest incidence of genital chlamydial infection was reported in the 20-24-year age group (184.70 cases per 100,000 population), followed by the 25-29-year age group (180.79 cases per 100,000) and 30-34-year age group (151.53 cases per 100,000 population). The highest proportion (68.30%) of genital chlamydial infection was reported from general hospitals, followed by maternal and child health hospitals (25.59%).Conclusion:The incidence rate of genital chlamydial infection in 2019 has an increase trend from 2018 and be a common sexually transmitted infection in China. The incidence is much higher in females than in males. Sexually active young adults are the highest risk population. There is substantial geographic diversity in incidence, with the highest incidence occurring in the southeast coastal areas with a developed economy. Epidemic of genital chlamydial infection in China should be concerned, and its surveillance needs to be improved.

简介：AbstractSystemic lupus erythematosus (SLE) is an autoimmune disease with extreme heterogeneity and potentially involvement of any organ or system. Numerous unanswered questions and challenges in SLE always prompt further exploration. In 2019, great progress in various aspects of SLE emerged. Both the classification criteria and management recommendation for SLE were updated. New promising medications have been widely developed and tested, although subsequent clinical studies are warranted. As an emerging number of most notable studies in SLE were published in both clinical area and basic research in 2019, we aim to summarize the highest quality data on SLE regarding novel insights of pathogenesis, updated recommendations, hot-spot issues on clinical manifestations, new understanding of disease prognosis, and most importantly, the therapeutic advances in SLE in this review.

简介：摘 要：干挂石材幕墙与传统幕墙施工工艺相比，既降低了操作难度，又能更好地保证幕墙施工质量，达到预定效果，减少后期运营阶段的质量问题。本文结合青浦新城 63A-03A地块工程实例 .从后置埋件、以及骨架安装、石材安装、密封胶浇注等方面，探讨了幕墙施工中石材干挂技术施工控制要点，可供类似工程参考借鉴。

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简介：AbstractBackground:Medicines for the treatment of 2019-novel coronavirus (2019-nCoV) infections are urgently needed. However, drug screening using live 2019-nCoV requires high-level biosafety facilities, which imposes an obstacle for those institutions without such facilities or 2019-nCoV. This study aims to repurpose the clinically approved drugs for the treatment of coronavirus disease 2019 (COVID-19) in a 2019-nCoV-related coronavirus model.Methods:A 2019-nCoV-related pangolin coronavirus GX_P2V/pangolin/2017/Guangxi was described. Whether GX_P2V uses angiotensin-converting enzyme 2 (ACE2) as the cell receptor was investigated by using small interfering RNA (siRNA)-mediated silencing of ACE2. The pangolin coronavirus model was used to identify drug candidates for treating 2019-nCoV infection. Two libraries of 2406 clinically approved drugs were screened for their ability to inhibit cytopathic effects on Vero E6 cells by GX_P2V infection. The anti-viral activities and anti-viral mechanisms of potential drugs were further investigated. Viral yields of RNAs and infectious particles were quantified by quantitative real-time polymerase chain reaction (qRT-PCR) and plaque assay, respectively.Results:The spike protein of coronavirus GX_P2V shares 92.2% amino acid identity with that of 2019-nCoV isolate Wuhanhu-1, and uses ACE2 as the receptor for infection just like 2019-nCoV. Three drugs, including cepharanthine (CEP), selamectin, and mefloquine hydrochloride, exhibited complete inhibition of cytopathic effects in cell culture at 10 μmol/L. CEP demonstrated the most potent inhibition of GX_P2V infection, with a concentration for 50% of maximal effect [EC50] of 0.98 μmol/L. The viral RNA yield in cells treated with 10 μmol/L CEP was 15,393-fold lower than in cells without CEP treatment ([6.48 ± 0.02] × 10-4vs. 1.00 ± 0.12, t= 150.38, P < 0.001) at 72 h post-infection (p.i.). Plaque assays found no production of live viruses in media containing 10 μmol/L CEP at 48 h p.i. Furthermore, we found CEP had potent anti-viral activities against both viral entry (0.46 ± 0.12, vs.1.00 ± 0.37, t = 2.42, P < 0.05) and viral replication ([6.18 ± 0.95] × 10-4vs. 1.00 ± 0.43, t= 3.98, P < 0.05).Conclusions:Our pangolin coronavirus GX_P2V is a workable model for 2019-nCoV research. CEP, selamectin, and mefloquine hydrochloride are potential drugs for treating 2019-nCoV infection. Our results strongly suggest that CEP is a wide-spectrum inhibitor of pan-betacoronavirus, and further study of CEP for treatment of 2019-nCoV infection is warranted.

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